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9/8/2023 9:45:24 AM | Browse: 109 | Download: 245
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Received |
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2023-06-25 15:51 |
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Peer-Review Started |
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2023-06-25 15:54 |
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To Make the First Decision |
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Return for Revision |
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2023-07-18 07:34 |
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Revised |
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2023-08-16 07:30 |
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Second Decision |
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2023-08-25 02:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-08-25 07:37 |
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Articles in Press |
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2023-08-25 07:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-28 17:48 |
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Publish the Manuscript Online |
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2023-09-08 09:38 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Multinucleated giant cells of bladder mucosa are modified telocytes: Diagnostic and immunohistochemistry algorithm and relation to PD-L1 expression score
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Milena Gulinac, Tsvetelina Velikova and Dorian Dikov |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| European Union-NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria |
BG-RRP-2.004-0008-C01 |
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| Corresponding Author |
Milena Gulinac, MD, PhD, Assistant Professor, Doctor, General and Clinical Pathology, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, Plovdiv 4002, Bulgaria. mgulinac@hotmail.com |
| Key Words |
Multinucleated giant cells; Telocytes; Urothelial bladder carcinoma; Immunohistochemical; Vimentin; Smooth muscle actin; Desmin; CD34; CD68; p16; Algorithm; PD-L1; Chronic inflammation |
| Core Tip |
Based on our results and data from the literature, we have developed and proposed an algorithm of histological, histochemical, and immunohistochemical (IHC) criteria, and also a generalized algorithm for the differential diagnosis of multinucleated giant cells (MGCs) in bladder urothelial carcinoma and benign or malignant lesions of other visceral organs. According to the data obtained by us in the morphological and IHC study, MGCS are modified telocytes. The reason for this modification is the chronic damage to the bladder mucosa (regardless of the etiological factor), which leads to the fusion of telocytes and their transformation into multinucleated cells. At the same time, they lose C-kit expression, penetrate phagocytic function, and begin to express p16, which is, as described in detail above, a sign of cellular aging. |
| Publish Date |
2023-09-08 09:38 |
| Citation |
Gulinac M, Velikova T, Dikov D. Multinucleated giant cells of bladder mucosa are modified telocytes: Diagnostic and immunohistochemistry algorithm and relation to PD-L1 expression score. World J Clin Cases 2023; 11(26): 6091-6104 |
| URL |
https://www.wjgnet.com/2307-8960/full/v11/i26/6091.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i26.6091 |
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