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3/12/2024 12:31:14 PM | Browse: 80 | Download: 97
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Received |
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2023-09-07 15:33 |
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Peer-Review Started |
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2023-09-07 15:34 |
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To Make the First Decision |
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Return for Revision |
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2023-12-05 06:14 |
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Revised |
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2023-12-16 09:31 |
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Second Decision |
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2024-02-02 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2024-02-02 06:07 |
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Articles in Press |
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2024-02-02 06:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-03-04 06:52 |
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Publish the Manuscript Online |
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2024-03-12 10:04 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemical Research Methods |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Construction of an immune-related gene signature for overall survival prediction and immune infiltration in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Ting Ma, Xiu Liu, Kai Ou and Lin Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing CSCO Clinical Oncology Research Foundation |
No. Y-HH202102-0308 |
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| Corresponding Author |
Lin Yang, Doctor, Doctor, Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. linyangcicams@126.com |
| Key Words |
Differentially expressed immune-related gene; Immunotherapy; Gastric cancer; Risk score |
| Core Tip |
We ultimately obtained an Immune Related Signature based on 10 genes, including 9 risk genes (LCN1, LEAP2, TMSB15A mRNA, DEFB126, PI15, IGHD3-16, IGLV3-22, CGB5, GLP2R) and 1 protective gene (LGR6). Kaplan-Meier survival analysis, ROC analysis and risk curve confirmed that the risk model has good predictive ability. Multivariate COX analysis showed that age, stage and risk score were independent prognostic factors. Patients in the low-risk group had higher tumor mutation burden and immunophenotype score, which can be used to predict immune checkpoint inhibitor response. Both cytotoxic T lymphocyte antigen4+ and programmed death 1+ patients with lower risk scores were more sensitive to immunotherapy. |
| Publish Date |
2024-03-12 10:04 |
| Citation |
Ma XT, Liu X, Ou K, Yang L. Construction of an immune-related gene signature for overall survival prediction and immune infiltration in gastric cancer. World J Gastrointest Oncol 2024; 16(3): 919-932 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i3/919.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i3.919 |
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