Publication Name	World Journal of Transplantation
Manuscript ID	86645
Country	United Kingdom

Received	2023-06-30 17:59
Peer-Review Started	2023-06-30 18:03
To Make the First Decision
Return for Revision	2023-07-28 08:55
Revised	2023-08-01 20:08
Second Decision	2023-08-18 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-08-18 09:27
Articles in Press	2023-08-18 09:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-09-11 10:32
Publish the Manuscript Online	2023-09-15 04:42

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Evidence Review
Article Title	Simultaneous pancreas-kidney transplantation for end-stage renal failure in type 1 diabetes mellitus: Current perspectives
Manuscript Source	Invited Manuscript
All Author List	Lakshmi Nagendra, Cornelius James Fernandez and Joseph M Pappachan
Funding Agency and Grant Number
Corresponding Author	Joseph M Pappachan, FRCP, MD, Academic Editor, Professor, Senior Researcher, Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Sharoe Green Lane , Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in
Key Words	Type 1 diabetes mellitus; Chronic kidney disease; End-stage renal failure; Simultaneous pancreas-kidney transplantation; Perioperative complications; Immunosuppression
Core Tip	Simultaneous pancreas-kidney transplant (SPKT) is a promising management option for patients with advanced chronic kidney disease or end-stage renal failure (CKD/ESRF) and type 1 diabetes mellitus (T1DM) for probable cure of these diseases and possibly some of their complications. However, limited availability of these organs, need for long-term immunosuppression, the surgical complications, lack of availability of this procedure in most centers, and the cost implications related to SPKT are major challenges across the world. This clinical update review is to enable clinicians with the best evidence and current recommendations of SPKT for managing their patients with T1DM and advanced CKD/ESRF.
Publish Date	2023-09-15 04:42
Citation	Nagendra L, Fernandez CJ, Pappachan JM. Simultaneous pancreas-kidney transplantation for end-stage renal failure in type 1 diabetes mellitus: Current perspectives. World J Transplant 2023; 13(5): 208-220
URL	https://www.wjgnet.com/2220-3230/full/v13/i5/208.htm
DOI	https://dx.doi.org/10.5500/wjt.v13.i5.208

Full Article (PDF)	WJT-13-208-with-cover.pdf
Full Article (Word)	WJT-13-208.docx
Manuscript File	86645_Auto_Edited-LJH-JLW.docx
Answering Reviewers	86645-Answering reviewers.pdf
Audio Core Tip	86645-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	86645-Conflict-of-interest statement.pdf
Copyright License Agreement	86645-Copyright license agreement.pdf
Peer-review Report	86645-Peer-review(s).pdf
Scientific Misconduct Check	86645-Bing-Liu JH-2.png
Scientific Misconduct Check	86645-CrossCheck.png
Scientific Editor Work List	86645-Scientific editor work list.pdf
CrossCheck Report	86645-CrossCheck report.pdf