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9/14/2023 3:00:54 PM | Browse: 511 | Download: 1716
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Received |
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2023-07-05 05:42 |
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Peer-Review Started |
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2023-07-05 05:44 |
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First Decision by Editorial Office Director |
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2023-08-10 17:11 |
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Return for Revision |
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2023-08-10 17:11 |
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Revised |
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2023-08-23 15:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-09-05 02:51 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-09-05 07:41 |
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Articles in Press |
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2023-09-05 07:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-08 08:38 |
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Publish the Manuscript Online |
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2023-09-14 14:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Heparanase inhibition leads to improvement in patients with acute gastrointestinal injuries induced by sepsis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting-Ting Chen, Jia-Jun Lv, Ling Chen, Min Li and Li-Ping Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Department of Gansu Province |
20JR5RA35 |
| Science and Technology Project of Gansu Province |
22JR10KA009 |
| Talent Innovation and Entrepreneurship Project of Science and Technology Bureau of Chengguan District, Lanzhou |
2020RCCX0030 |
| Lanzhou Science and Technology Development Guiding Plan Project |
2019-ZD-37 |
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| Corresponding Author |
Li-Ping Liu, MD, PhD, Doctor, Doctor, Department of Emergency Critical Care Medicine, The First Hospital of Lanzhou University, No. 1 West Road, Donggang, Chengguan District, Lanzhou 730000, Gansu Province, China. liulipingldyy@126.com |
| Key Words |
Sepsis; Acute gastrointestinal injury; Heparanase; Autophagy |
| Core Tip |
Heparanase (HPA) plays an important role in the occurrence and development of septic acute gastrointestinal injury (S-AGI). Our experimental results show that HPA has great potential as a diagnostic marker for S-AGI. Inhibition of HPA activity reduces syndecan-1 shedding, reduces inflammatory response, improves coagulation and immune function, and alleviates S-AGI symptoms. The inhibitory effect of HPA on gastrointestinal protection may be achieved by increasing the level of autophagy. |
| Publish Date |
2023-09-14 14:58 |
| Citation |
Chen TT, Lv JJ, Chen L, Li M, Liu LP. Heparanase inhibition leads to improvement in patients with acute gastrointestinal injuries induced by sepsis. World J Gastroenterol 2023; 29(35): 5154-5165
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| URL |
https://www.wjgnet.com/1007-9327/full/v29/i35/5154.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i35.5154 |
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