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9/14/2023 3:00:54 PM | Browse: 150 | Download: 357
Publication Name World Journal of Gastroenterology
Manuscript ID 86738
Country China
Received
2023-07-05 05:42
Peer-Review Started
2023-07-05 05:44
To Make the First Decision
Return for Revision
2023-08-10 17:11
Revised
2023-08-23 15:12
Second Decision
2023-09-05 02:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-09-05 07:41
Articles in Press
2023-09-05 07:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-09-08 08:38
Publish the Manuscript Online
2023-09-14 14:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Critical Care Medicine
Manuscript Type Clinical Trials Study
Article Title Heparanase inhibition leads to improvement in patients with acute gastrointestinal injuries induced by sepsis
Manuscript Source Unsolicited Manuscript
All Author List Ting-Ting Chen, Jia-Jun Lv, Ling Chen, Min Li and Li-Ping Liu
Funding Agency and Grant Number
Funding Agency Grant Number
Science and Technology Department of Gansu Province 20JR5RA35
Science and Technology Project of Gansu Province 22JR10KA009
Talent Innovation and Entrepreneurship Project of Science and Technology Bureau of Chengguan District, Lanzhou 2020RCCX0030
Lanzhou Science and Technology Development Guiding Plan Project 2019-ZD-37
Corresponding Author Li-Ping Liu, MD, PhD, Doctor, Department of Emergency Critical Care Medicine, The First Hospital of Lanzhou University, No. 1 West Road, Donggang, Chengguan District, Lanzhou 730000, Gansu Province, China. liulipingldyy@126.com
Key Words Sepsis; Acute gastrointestinal injury; Heparanase; Autophagy
Core Tip Heparanase (HPA) plays an important role in the occurrence and development of septic acute gastrointestinal injury (S-AGI). Our experimental results show that HPA has great potential as a diagnostic marker for S-AGI. Inhibition of HPA activity reduces syndecan-1 shedding, reduces inflammatory response, improves coagulation and immune function, and alleviates S-AGI symptoms. The inhibitory effect of HPA on gastrointestinal protection may be achieved by increasing the level of autophagy.
Publish Date 2023-09-14 14:58
Citation Chen TT, Lv JJ, Chen L, Li M, Liu LP. Heparanase inhibition leads to improvement in patients with acute gastrointestinal injuries induced by sepsis. World J Gastroenterol 2023; 29(35): 5154-5165
URL https://www.wjgnet.com/1007-9327/full/v29/i35/5154.htm
DOI https://dx.doi.org/10.3748/wjg.v29.i35.5154
Full Article (PDF) WJG-29-5154-with-cover.pdf
Full Article (Word) WJG-29-5154.docx
CONSORT 2010 Statement 86738-CONSORT 2010 statement.pdf
Manuscript File 86738_Auto_Edited-JLW.docx
Answering Reviewers 86738-Answering reviewers.pdf
Audio Core Tip 86738-Audio core tip.mp3
Biostatistics Review Certificate 86738-Biostatistics statement.pdf
Clinical Trial Registration Statement 86738-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 86738-Conflict-of-interest statement.pdf
Copyright License Agreement 86738-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 86738-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 86738-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 86738-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 86738-Language certificate.pdf
Peer-review Report 86738-Peer-review(s).pdf
Scientific Misconduct Check 86738-Bing-Wang JJ-2.png
Scientific Editor Work List 86738-Scientific editor work list.pdf
CrossCheck Report 86738-CrossCheck report.pdf