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11/28/2023 2:00:29 AM | Browse: 132 | Download: 275
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Received |
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2023-07-20 14:17 |
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Peer-Review Started |
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2023-07-20 14:19 |
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To Make the First Decision |
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Return for Revision |
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2023-10-09 20:34 |
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Revised |
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2023-10-23 04:02 |
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Second Decision |
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2023-11-09 01:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-11-14 08:29 |
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Articles in Press |
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2023-11-14 08:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-11-22 03:46 |
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Publish the Manuscript Online |
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2023-11-27 17:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ruo-Chuan Sun, Jing Li, Ya-Xian Li, Hui-Zhen Wang, Emre Dal, Ming-Liang Wang and Yong-Xiang Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Key Programs of the Educational Commission of Anhui Province |
2023AH053313 |
| the Research Project of Higher Education in Anhui Province in 2022 |
2022AH051192 |
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| Corresponding Author |
Yong-Xiang Li, Doctor, N/A, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230022, Anhui Province, China. liyongxiang@ahmu.edu.cn |
| Key Words |
Gastric cancer; Tousled-like kinase 1; Tumor growth factor-beta; Tumour progression; Targeted therapy |
| Core Tip |
We demonstrated that Tousled-like kinase 1 (TLK1) is highly expressed in gastric cancer (GC), localized mainly to the nucleus, significantly promotes GC cell proliferation, invasion, and migration, and inhibits apoptosis. TLK1 may facilitate GC progression by modulating tumor growth factor-beta expression. We believe that TLK1 could be a crucial therapeutic target for GC, and propose that future investigations evaluate the feasibility and practicality of targeting TLK1 in GC treatment. |
| Publish Date |
2023-11-27 17:08 |
| Citation |
Sun RC, Li J, Li YX, Wang HZ, Dal E, Wang ML, Li YX. Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway. World J Gastroenterol 2023; 29(44): 5919-5934 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i44/5919.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i44.5919 |
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