Publication Name	World Journal of Gastroenterology
Manuscript ID	86896
Country	China

Received	2023-07-20 03:01
Peer-Review Started	2023-07-14 01:45
To Make the First Decision
Return for Revision	2023-09-06 00:20
Revised	2023-09-11 15:16
Second Decision	2023-09-27 10:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-10-11 06:09
Articles in Press	2023-10-11 06:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-10-17 00:11
Publish the Manuscript Online	2023-10-19 16:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Microbiology
Manuscript Type	Basic Study
Article Title	Enhanced glucose homeostasis via Clostridium symbiosum-mediated glucagon-like peptide 1 inhibition of hepatic gluconeogenesis in mid-intestinal bypass surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Xin Luo, Fang Tao, Cai Tan, Chi-Ying Xu, Zhi-Hua Zheng, Qiang Pang, Xiang-An He, Jia-Qing Cao and Jin-Yuan Duan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82060161, 81960154, 81760156 Jiangxi Provincial Youth Science Foundation 2018ACB21040 Foundation of Health commission of Jiangxi Province SKJP220225830 Natural Science Foundation of Jiangxi Province 20212BAB206020
Corresponding Author	Jin-Yuan Duan, PhD, Associate Chief Physician, Department of General Surgery, The First Affiliated Hospital of Nanchang University, No. 1519 Dongyue Avenue, Nanchang 330000, Jiangxi Province, China. duanjy2022@outlook.com
Key Words	Gut micobiome; Glucagon-like peptide-1; Glucose metablism; Bile acid; Bariatric surgery; Gluconeogenesis
Core Tip	Intestinal function plays a pivotal role in the onset, progression, and alleviation of diabetes. However, research on surgical procedures and functions involving the mid-small intestine is limited. The precise mechanisms by which the mid-small intestine improves glucose metabolism in diabetic rats remain largely unclear. This study explores the effects of mid-small intestine bypass surgery on diabetic rats. Post-surgery, there was an increase in the abundance of Clostridium symbiosum in the rat gut, which contributed to improved glucose metabolism through the inhibition of hepatic gluconeogenesis mediated by glucagon-like peptide 1. These findings provide a theoretical basis for non-surgical interventions in the treatment of metabolic disorders associated with diabetes.
Publish Date	2023-10-19 16:26
Citation	Luo X, Tao F, Tan C, Xu CY, Zheng ZH, Pang Q, He XA, Cao JQ, Duan JY. Enhanced glucose homeostasis via Clostridium symbiosum-mediated glucagon-like peptide 1 inhibition of hepatic gluconeogenesis in mid-intestinal bypass surgery. World J Gastroenterol 2023; 29(39): 5471-5482
URL	https://www.wjgnet.com/1007-9327/full/v29/i39/5471.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i39.5471

Full Article (PDF)	WJG-29-5471-with-cover.pdf
Full Article (Word)	WJG-29-5471.docx
The ARRIVE Guidelines	86896-The ARRIVE guidelines.pdf
Manuscript File	86896_Auto_Edited-JLW.docx
Answering Reviewers	86896-Answering reviewers.pdf
Audio Core Tip	86896-Audio core tip.mp3
Biostatistics Review Certificate	86896-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	86896-Conflict-of-interest statement.pdf
Copyright License Agreement	86896-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	86896-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	86896-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	86896-Language certificate.pdf
Peer-review Report	86896-Peer-review(s).pdf
Scientific Misconduct Check	86896-Bing-Wang JJ-2.png
Scientific Editor Work List	86896-Scientific editor work list.pdf