Publication Name	World Journal of Gastroenterology
Manuscript ID	87035
Country	Malaysia

Received	2023-07-20 08:59
Peer-Review Started	2023-07-20 09:03
To Make the First Decision
Return for Revision	2023-08-25 04:43
Revised	2023-09-05 04:51
Second Decision	2023-09-28 07:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-10-11 06:15
Articles in Press	2023-10-11 06:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-10-17 07:23
Publish the Manuscript Online	2023-10-27 15:28

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Roles of phosphatidylinositol-3-kinases signaling pathway in inflammation-related cancer: Impact of rs10889677 variant and buparlisib in colitis-associated cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Nurul Nadirah Razali, Raja Affendi Raja Ali, Khairul Najmi Muhammad Nawawi, Azyani Yahaya, Norshafila Diana Mohd Rathi and Norfilza Mohd Mokhtar
Funding Agency and Grant Number	Funding Agency Grant Number The Fundamental Research Grant Scheme, Ministry of Higher Education, Malaysia FRGS/1/2018/SKK06/UKM/02/4
Corresponding Author	Norfilza Mohd Mokhtar, PhD, Professor, Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, Malaysia. norfilza@ppukm.ukm.edu.my
Key Words	Colitis-associated cancer; Colorectal cancer; Phosphatidylinositol 3-kinase; Animal model; Luciferases; Renilla; Phosphatidylinositol 3-kinase inhibitor
Core Tip	The role of phosphatidylinositol-3-kinases (PI3K) in promoting cancer progression has been widely acknowledged due to its crucial involvement in regulating the survival, differentiation, and proliferation of cancer cells. Here, we investigate the role of PI3K signaling in colitis-associated cancer (CAC) pathogenesis by studying the regulation of potential variant in PI3K-related gene in the colorectal cancer cell line and the utilization of PI3K inhibitor, buparlisib, in the CAC-induced mice model. We suggested that rs10889677 variant plays a crucial role in initiating the PI3K signaling pathway, and buparlisib has the capability to inhibit PI3K-non-AKT activation in the pathophysiology of CAC.
Publish Date	2023-10-27 15:28
Citation	Razali NN, Raja Ali RA, Muhammad Nawawi KN, Yahaya A, Mohd Rathi ND, Mokhtar NM. Roles of phosphatidylinositol-3-kinases signaling pathway in inflammation-related cancer: Impact of rs10889677 variant and buparlisib in colitis-associated cancer. World J Gastroenterol 2023; 29(40): 5543-5556
URL	https://www.wjgnet.com/1007-9327/full/v29/i40/5543.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i40.5543

Full Article (PDF)	WJG-29-5543-with-cover.pdf
Full Article (Word)	WJG-29-5543.docx
The ARRIVE Guidelines	87035-The ARRIVE guidelines.pdf
Manuscript File	87035_Auto_Edited-JLW.docx
Answering Reviewers	87035-Answering reviewers.pdf
Audio Core Tip	87035-Audio core tip.m4a
Biostatistics Review Certificate	87035-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	87035-Conflict-of-interest statement.pdf
Copyright License Agreement	87035-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	87035-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	87035-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	87035-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	87035-Language certificate.pdf
Peer-review Report	87035-Peer-review(s).pdf
Scientific Misconduct Check	87035-Bing-Fan JR-2.png
Scientific Editor Work List	87035-Scientific editor work list.pdf
CrossCheck Report	87035-CrossCheck report.pdf
CrossCheck Report	87035-CrossCheck.png