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12/14/2023 1:40:26 PM | Browse: 383 | Download: 1609
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Received |
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2023-08-22 08:50 |
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Peer-Review Started |
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2023-08-22 08:52 |
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First Decision by Editorial Office Director |
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2023-09-18 22:12 |
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Return for Revision |
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2023-09-19 05:16 |
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Revised |
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2023-09-28 12:11 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-11-16 02:23 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-11-27 06:41 |
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Articles in Press |
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2023-11-27 06:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-08 06:16 |
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Publish the Manuscript Online |
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2023-12-14 09:36 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Depletion of gut microbiota facilitates fibroblast growth factor 21-mediated protection against acute pancreatitis in diabetic mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qi-Yan Sun, Xu-Ye Wang, Zu-Pin Huang, Jing Song, En-Dong Zheng, Fang-Hua Gong and Xiao-Wang Huang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the 2022 Zhejiang Provincial Health Science and Technology Plan |
2022KY1216 |
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| Corresponding Author |
Fang-Hua Gong, MD, Associate Professor, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China. gongwenheng@163.com |
| Key Words |
Acute pancreatitis; Fibroblast growth factor 21; Gut microbiota; Diabetes; PICRUSt2; Cocktail of antibiotics |
| Core Tip |
This study reveals the potential of facilitates fibroblast growth factor 21 (FGF21) in improving pancreatic and intestinal damage recovery, reducing blood glucose levels, and reshaping gut microbiota composition in diabetic mice with acute pancreatitis (AP). Notably, the protective effects of FGF21 are augmented when combined with the Abx cocktail. These findings provide new insights into the prevention and treatment of diabetes complicated by AP. |
| Publish Date |
2023-12-14 09:36 |
| Citation |
Sun QY, Wang XY, Huang ZP, Song J, Zheng ED, Gong FH, Huang XW. Depletion of gut microbiota facilitates fibroblast growth factor 21-mediated protection against acute pancreatitis in diabetic mice. World J Diabetes 2023; 14(12): 1824-1838
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| URL |
https://www.wjgnet.com/1948-9358/full/v14/i12/1824.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i12.1824 |
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