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1/23/2024 7:29:32 AM | Browse: 60 | Download: 148
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Received |
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2023-09-11 04:53 |
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Peer-Review Started |
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2023-09-11 04:55 |
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To Make the First Decision |
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Return for Revision |
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2023-11-23 00:42 |
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Revised |
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2023-12-03 08:11 |
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Second Decision |
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2023-12-19 02:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-12-29 07:15 |
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Articles in Press |
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2023-12-29 07:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-01-13 12:46 |
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Publish the Manuscript Online |
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2024-01-23 04:13 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Prognostic and immunological roles of heat shock protein A4 in lung adenocarcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xuan Wu, Shen-Ying Yang, Yi-Hua Zhang, Jin-Zhou Fang, Shuai Wang, Zhi-Wei Xu and Xiao-Ju Zhang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao-Ju Zhang, Doctor, PhD, Academic Research, Additional Professor, Chief Physician, Department of Pulmonary and Critical Care Medicine, Zhengzhou University People’s Hospital, No. 7 Weiwu Road, Jinshui District, Zhengzhou 450008, Henan Province, China. zhangxiaoju@zzu.edu.cn |
| Key Words |
Heat shock protein A4; Lung adenocarcinoma; Tumor-infiltration; Prognosis; T helper cells |
| Core Tip |
Overexpressing heat shock protein A4 (HSPA4) was significantly related to advanced pathologic TNM stage, advanced pathologic stage, progression disease status of primary therapy outcome and female subgroups with lung adenocarcinoma. In addition, increased HSPA4 expression was also found to be related to worse disease-specific survival and overall survival. Gene set enrichment analysis analysis indicated a significant correlation between HSPA4 and cell cycle regulation and immune response, particularly through diminishing the function of cytotoxicity cells and CD8 T cells. The single-sample gene set enrichment analysis algorithm showed a positive correlation between HSPA4 expression and infiltrating levels of Th2 cells, while a negative correlation was observed with cytotoxic cell infiltration levels. |
| Publish Date |
2024-01-23 04:13 |
| Citation |
Wu X, Yang SY, Zhang YH, Fang JZ, Wang S, Xu ZW, Zhang XJ. Prognostic and immunological roles of heat shock protein A4 in lung adenocarcinoma. World J Clin Oncol 2024; 15(1): 45-61 |
| URL |
https://www.wjgnet.com/2218-4333/full/v15/i1/45.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v15.i1.45 |
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