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12/18/2023 9:47:20 AM | Browse: 243 | Download: 654
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Received |
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2023-09-22 02:55 |
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Peer-Review Started |
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2023-09-22 02:57 |
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To Make the First Decision |
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Return for Revision |
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2023-10-24 09:10 |
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Revised |
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2023-11-01 05:08 |
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Second Decision |
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2023-11-21 02:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-12-01 07:17 |
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Articles in Press |
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2023-12-01 07:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-13 14:38 |
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Publish the Manuscript Online |
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2023-12-18 07:44 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Pathophysiology of acute graft-versus-host disease from the perspective of hemodynamics determined by dielectric analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Masayuki Nagasawa |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant-in-Aid for Scientific Research of Japan (KAKENHI) |
2459154 |
| Grant-in-Aid for Scientific Research of Japan (KAKENHI) |
15K09639 |
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| Corresponding Author |
Masayuki Nagasawa, MD, PhD, Chief Physician, Department of Pediatrics, Musashino Red Cross Hospital, 1-26-1, Kyonan-cho, Musashino City 180-8610, Tokyo, Japan. mnagasawa.ped@tmd.ac.jp |
| Key Words |
Graft-versus-host disease; Dielectric relaxation; Erythrocyte; Stem cell transplantation; Coagulation |
| Core Tip |
The pathophysiology of graft-versus-host disease (GVHD) is complex. Examination of changes in the dielectric properties of whole blood revealed that erythrocytes formed risky levels of rouleaux and aggregates in severe GVHD. In severe GVHD, oxidative stress causes degradation of erythrocyte band3 and truncation of the C-terminus of peroxiredoxin 2, resulting in decreased plasticity, increased fragility, and reduced oxygen-carrying capacity. These phenomena may underlie persistent refractory coagulopathy and circulation disorder, leading to organ damage in severe GVHD. |
| Publish Date |
2023-12-18 07:44 |
| Citation |
Nagasawa M. Pathophysiology of acute graft-versus-host disease from the perspective of hemodynamics determined by dielectric analysis. World J Transplant 2023; 13(6): 379-390 |
| URL |
https://www.wjgnet.com/2220-3230/full/v13/i6/379.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v13.i6.379 |
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