Publication Name	World Journal of Experimental Medicine
Manuscript ID	88378
Country	India

Received	2023-09-22 09:28
Peer-Review Started	2023-09-22 09:31
To Make the First Decision
Return for Revision	2023-09-29 03:07
Revised	2023-10-04 15:55
Second Decision	2023-10-27 06:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-10-30 07:43
Articles in Press	2023-10-30 07:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-12-14 04:03
Publish the Manuscript Online	2023-12-19 06:07

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Integrative & Complementary Medicine
Manuscript Type	Basic Study
Article Title	Exploring the mechanism of action bitter melon in the treatment of breast cancer by network pharmacology
Manuscript Source	Invited Manuscript
All Author List	Kavan Panchal, Bhavya Nihalani, Utsavi Oza, Aarti Panchal and Bhumi Shah
Funding Agency and Grant Number
Corresponding Author	Bhumi Shah, PhD, Associate Professor, Pharmaceutical Chemistry, L. J. Institute of Pharmacy, Sanand Circle, Sarkhej-Gandhinagar Hwy, Sarkhej, Ahmedabad 382210, Gujarat, India. bhumi197@gmail.com
Key Words	Bitter melon; Momordica charantia; Network pharmacology; Molecular docking; Breast cancer; Indian Medicinal Plants, Phytochemistry and Therapeutics
Core Tip	The phytochemicals and molecular processes in bitter melon that are thought to be involved in the therapy of breast cancer (BRCA) were investigated using network Pharmacology. Our research demonstrated that the anti-BRCA benefits of bitter melon are likely caused by negative regulation of transcription, cell differentiation, apoptosis, proteolysis, negative control of neuron apoptosis, and cell migration. Further discovered nine important pathways like phosphatidylinositol 3-kinase/protein kinase B signaling, transcriptional dysregulation, axon guidance, calcium signaling, focal adhesion, janus kinase-signal transducer and activator of transcription signaling, cyclic adenosine monophosphate signaling, mammalian target of rapamycin signaling, and phospholipase D signaling, are likely to be involved in the mechanism of action of bitter melon for the treatment of BRCA.
Publish Date	2023-12-19 06:07
Citation	Panchal K, Nihalani B, Oza U, Panchal A, Shah B. Exploring the mechanism of action bitter melon in the treatment of breast cancer by network pharmacology. World J Exp Med 2023; 13(5): 142-155
URL	https://www.wjgnet.com/2220-315x/full/v13/i5/142.htm
DOI	https://dx.doi.org/10.5493/wjem.v13.i5.142

Full Article (PDF)	WJEM-13-142-with-cover.pdf
Full Article (Word)	WJEM-13-142.docx
Manuscript File	88378_Auto_Edited-JLW.docx
Answering Reviewers	88378-Answering reviewers.pdf
Audio Core Tip	88378-Audio core tip.mp3
Biostatistics Review Certificate	88378-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88378-Conflict-of-interest statement.pdf
Copyright License Agreement	88378-Copyright license agreement.pdf
Peer-review Report	88378-Peer-review(s).pdf
Scientific Misconduct Check	88378-Bing-Qu XL-2.jpg
Scientific Editor Work List	88378-Scientific editor work list.pdf