| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Yinhuang granule alleviates carbon tetrachloride-induced liver fibrosis in mice and its mechanism
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hao Ouyang, Hui Miao, Zhen Li, Duan Wu, Si-Cheng Gao, Yao-Yao Dai, Xiao-Di Gao, Hai-Sheng Chai, Wei-Ye Hu and Jun-Feng Zhu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| preclinical study of a new Chinese herbal medicine for the treatment of ascites of liver cirrhosis (spleen and kidney yang deficiency type) with the clinical formula of Qigui Xiaogu Cataplasm |
No.23S21900100 |
| Traditional Chinese Medicine/ Chinese and Western Medicine advantage specialty construction specialty for department of hepatology |
YW(2023-2024)-01-03 |
| National Natural Science Foundation of China |
82074386 |
| Construction of special disease alliance of traditional Chinese medicine in East China area and municipal level, Shanghai special disease alliance of traditional Chinese medicine for liver cirrhosis ascites (Water sickness) |
|
| Clinical Research Plan of SHDC |
No. SHDC2020CR3095B |
|
| Corresponding Author |
Jun-Feng Zhu, Doctor, Chief Physician, Department of Liver, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No. 110 Ganhe Road, Hongkou District, Shanghai 201203, China. zhujftongling@163.com |
| Key Words |
Yinhuang granule; Liver fibrosis; Hepatic stellate cells; Oxidative injury; Nuclear factor erythroid 2-related factor 2; Inflammation |
| Core Tip |
Yinhuang granule (YHG), a Chinese patent medicine comprising Scutellariae Radix and Lonicerae Japonicae Flos, is traditionally employed for the management of tonsillitis, pharyngitis, as well as upper respiratory tract infections in clinical practice. Here, our study found that YHG effectively alleviated liver fibrosis in carbon tetrachloride-treated mice through various mechanisms, including the inhibition of hepatic stellate cells activation, reduction of inflammation, alleviation of liver oxidative stress damage by prompting nuclear factor erythroid 2-related factor 2 activation, and promotion of liver mitochondrial biogenesis. These findings substantiate the potential clinical use of YHG as a therapy for liver fibrosis. |
| Publish Date |
2024-02-27 11:58 |
| Citation |
Ouyang H, Miao H, Li Z, Wu D, Gao SC, Dai YY, Gao XD, Chai HS, Hu WY, Zhu JF. Yinhuang granule alleviates carbon tetrachloride-induced liver fibrosis in mice and its mechanism. World J Hepatol 2024; 16(2): 264-278 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i2/264.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i2.264 |
