Publication Name	World Journal of Clinical Cases
Manuscript ID	88580
Country	China

Received	2023-10-12 03:52
Peer-Review Started	2023-09-29 21:50
To Make the First Decision
Return for Revision	2023-12-18 01:08
Revised	2023-12-18 05:36
Second Decision	2023-12-26 03:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-12-26 08:35
Articles in Press	2023-12-26 08:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-05 02:18
Publish the Manuscript Online	2024-01-11 05:28

ISSN	2307-8960 (online)
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Category	Oncology
Manuscript Type	Case Report
Article Title	Chemotherapy combined with bevacizumab for small cell lung cancer with brain metastases: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Yu Yang, Yu-Qing Xia, Yu-Jia Hou, Peng Xue, Shi-Jie Zhu and Dian-Rong Lu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81973640 Nursery Program of Wangjing Hospital, Chinese Academy of Traditional Chinese Medicine WJYY-YJKT-2022-05 Yu-Qing Xia Famous Old Chinese Medicine Heritage Workshop of “3+3” Project of Traditional Chinese Medicine Heritage in Beijing, Jing Zhong Yi Ke Zi (2021) 73 China Academy of Traditional Chinese Medicine Wangjing Hospital High-Level Chinese Medicine Hospital Construction Project Chinese Medicine Clinical Evidence-Based Research: The Evidence-Based Research of Electrothermal Acupuncture for Relieving Cancer-Related Fatigue in Patients With Malignant Tumor WYYY-XZKT-2023-20
Corresponding Author	Dian-Rong Lu, Doctor, PhD, Chief Physician, Professor, Department of Oncology, Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6 Huajiadi Street, Chaoyang District, Beijing 100102, China. ludianrong@aliyun.com
Key Words	Small cell lung cancer; Bevacizumab; Brain metastasis; Antineoplastic agents; Target therapies; Immunotherapy; Radiotherapy; Case report
Core Tip	Small cell lung cancer (SCLC) accounts for approximately 13%-15% of all lung cancer patients. A five-year survival rate of less than 7 percent makes it one of the deadliest cancers. Compared to Non-Small Cell Lung Carcinoma, SCLC has a faster doubling time in the early stages and is more likely to spread widely. Therefore, 60%-70% of SCLC is diagnosed as extensive stage at initial diagnosis. SCLC cells also show a high tendency of metastasis to the central nervous system, and 10% of patients have brain metastasis at the first visit. Here, we report a patient with extensive stage-small cell lung cancer (ES-SCLC) and brain metastases who received four lines of treatment. We used bevacizumab in combination with irinotecan as a post-fourth-line therapy in an elderly man and achieved a significant partial response.
Publish Date	2024-01-11 05:28
Citation	Yang HY, Xia YQ, Hou YJ, Xue P, Zhu SJ, Lu DR. Chemotherapy combined with bevacizumab for small cell lung cancer with brain metastases: A case report. World J Clin Cases 2023; 12(2): 405-411
URL	https://www.wjgnet.com/2307-8960/full/v12/i2/405.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i2.405

Full Article (PDF)	WJCC-12-405-with-cover.pdf
Full Article (Word)	WJCC-12-405.docx
CARE Checklist–2016	88580-CARE Checklist (2016).pdf
Manuscript File	88580_Auto_Edited-YJP.docx
Answering Reviewers	88580-Answering reviewers.pdf
Audio Core Tip	88580-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	88580-Conflict-of-interest statement.pdf
Copyright License Agreement	88580-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88580-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	88580-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	88580-Language certificate.pdf
Peer-review Report	88580-Peer-review(s).pdf
Scientific Misconduct Check	88580-Bing-Li L-2.png
Scientific Editor Work List	88580-Scientific editor work list.pdf