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2/4/2024 12:05:26 PM | Browse: 86 | Download: 90
Publication Name World Journal of Diabetes
Manuscript ID 88731
Country/Territory China
2023-10-10 08:34
Peer-Review Started
2023-10-10 08:35
To Make the First Decision
Return for Revision
2023-11-17 09:20
2023-12-12 01:59
Second Decision
2024-01-04 11:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-01-12 07:03
Articles in Press
2024-01-12 07:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2024-01-29 17:40
Publish the Manuscript Online
2024-02-04 10:57
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Basic Study
Article Title Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling
Manuscript Source Invited Manuscript
All Author List Huai-Jie Wang, Li-Bin Zhang, Si-Peng Sun, Qing-Tao Yan, Zhi-Qin Gao, Fang-Ming Fu and Mei-Hua Qu
Funding Agency and Grant Number
Funding Agency Grant Number
the Natural Science Foundation of China 82070856
the Science and Technology Development Plan of Shandong Medical and Health Science 202102040075
Scientific Research Plan of Weifang Health Commission WFWSJK-2022-010 and WFWSJK-2022-008
Weifang Science and Technology Development Plan 2021YX071 and 2021YX070
Corresponding Author Mei-Hua Qu, PhD, Professor, Translational Medical Center, Weifang Second People's Hospital, No. 7 Yuanxiao Street, Weifang 261041, Shandong Province, China. qumeihua2016@163.com
Key Words Duodenal jejunal bypass surgery; Type 2 diabetes mellitus; Neuron apoptosis; Inflammatory; Oxidative stress; Hypothalamic injury
Core Tip Duodenal jejunal bypass (DJB) increases serum glucagon-like peptide 1 (GLP-1) Levels and enhances brain glucose utilization, playing a positive role in the treatment of diabetes. The GLP-1 signal may play a significant role after DJB surgery in brain injury related to type 2 diabetes mellitus (T2DM). In the current study, DJB surgery increased the serum levels of GLP-1 and upregulated the expression of GLP-1 receptor and antioxidant signaling proteins (Nrf2 and HO-1) in the hypothalamic tissue of T2DM rats. DJB reduced the expression of hypothalamic inflammatory and nerve cell injury-related factors. Therefore, DJB surgery improve oxidative stress and inflammation in the hypothalamus of T2DM rats and reduce neuronal cell injury by activating the GLP-1-mediated Nrf2/HO-1 signaling pathway.
Publish Date 2024-02-04 10:57
Citation Wang HJ, Zhang LB, Sun SP, Yan QT, Gao ZQ, Fu FM, Qu MH. Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling. World J Diabetes 2024; 15(2): 287-304
URL https://www.wjgnet.com/1948-9358/full/v15/i2/287.htm
DOI https://dx.doi.org/10.4239/wjd.v15.i2.287
Full Article (PDF) WJD-15-287-with-cover.pdf
Full Article (Word) WJD-15-287.docx
The ARRIVE Guidelines 88731-The ARRIVE guidelines.pdf
Manuscript File 88731_Auto_Edited-YJP.docx
Answering Reviewers 88731-Answering reviewers.pdf
Audio Core Tip 88731-Audio core tip.mp3
Biostatistics Review Certificate 88731-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 88731-Conflict-of-interest statement.pdf
Copyright License Agreement 88731-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 88731-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 88731-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 88731-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 88731-Language certificate.pdf
Supplementary Material 88731-Supplementary material.pdf
Peer-review Report 88731-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 88731-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 88731-Bing-Li L-2.png
Scientific Editor Work List 88731-Scientific editor work list.pdf