Publication Name	World Journal of Diabetes
Manuscript ID	88731
Country	China

Received	2023-10-10 08:34
Peer-Review Started	2023-10-10 08:35
To Make the First Decision
Return for Revision	2023-11-17 09:20
Revised	2023-12-12 01:59
Second Decision	2024-01-04 11:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-12 07:03
Articles in Press	2024-01-12 07:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-29 17:40
Publish the Manuscript Online	2024-02-04 10:57

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling
Manuscript Source	Invited Manuscript
All Author List	Huai-Jie Wang, Li-Bin Zhang, Si-Peng Sun, Qing-Tao Yan, Zhi-Qin Gao, Fang-Ming Fu and Mei-Hua Qu
Funding Agency and Grant Number	Funding Agency Grant Number the Natural Science Foundation of China 82070856 the Science and Technology Development Plan of Shandong Medical and Health Science 202102040075 Scientific Research Plan of Weifang Health Commission WFWSJK-2022-010 and WFWSJK-2022-008 Weifang Science and Technology Development Plan 2021YX071 and 2021YX070
Corresponding Author	Mei-Hua Qu, PhD, Professor, Translational Medical Center, Weifang Second People's Hospital, No. 7 Yuanxiao Street, Weifang 261041, Shandong Province, China. qumeihua2016@163.com
Key Words	Duodenal jejunal bypass surgery; Type 2 diabetes mellitus; Neuron apoptosis; Inflammatory; Oxidative stress; Hypothalamic injury
Core Tip	Duodenal jejunal bypass (DJB) increases serum glucagon-like peptide 1 (GLP-1) Levels and enhances brain glucose utilization, playing a positive role in the treatment of diabetes. The GLP-1 signal may play a significant role after DJB surgery in brain injury related to type 2 diabetes mellitus (T2DM). In the current study, DJB surgery increased the serum levels of GLP-1 and upregulated the expression of GLP-1 receptor and antioxidant signaling proteins (Nrf2 and HO-1) in the hypothalamic tissue of T2DM rats. DJB reduced the expression of hypothalamic inflammatory and nerve cell injury-related factors. Therefore, DJB surgery improve oxidative stress and inflammation in the hypothalamus of T2DM rats and reduce neuronal cell injury by activating the GLP-1-mediated Nrf2/HO-1 signaling pathway.
Publish Date	2024-02-04 10:57
Citation	Wang HJ, Zhang LB, Sun SP, Yan QT, Gao ZQ, Fu FM, Qu MH. Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling. World J Diabetes 2024; 15(2): 287-304
URL	https://www.wjgnet.com/1948-9358/full/v15/i2/287.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i2.287

Full Article (PDF)	WJD-15-287-with-cover.pdf
Full Article (Word)	WJD-15-287.docx
The ARRIVE Guidelines	88731-The ARRIVE guidelines.pdf
Manuscript File	88731_Auto_Edited-YJP.docx
Answering Reviewers	88731-Answering reviewers.pdf
Audio Core Tip	88731-Audio core tip.mp3
Biostatistics Review Certificate	88731-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88731-Conflict-of-interest statement.pdf
Copyright License Agreement	88731-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88731-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	88731-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	88731-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	88731-Language certificate.pdf
Supplementary Material	88731-Supplementary material.pdf
Peer-review Report	88731-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	88731-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	88731-Bing-Li L-2.png
Scientific Editor Work List	88731-Scientific editor work list.pdf
CrossCheck Report	88731-CrossCheck report.pdf
CrossCheck Report	88731-CrossCheck.png