Publication Name	World Journal of Gastroenterology
Manuscript ID	88774
Country	China

Received	2023-10-08 15:37
Peer-Review Started	2023-10-08 15:39
To Make the First Decision
Return for Revision	2023-12-06 06:12
Revised	2023-12-18 14:53
Second Decision	2024-01-24 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-24 06:11
Articles in Press	2024-01-24 06:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-20 15:53
Publish the Manuscript Online	2024-02-26 13:28

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Metadherin promotes stem cell phenotypes and correlated with immune infiltration in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Yi-Ying Wang, Mei-Mei Shen and Jian Gao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82173359 Basic Research and Frontier Exploration Project of Chongqing and Technology Commission cstc2018jcyjAX0181 Kuanren Talents Program of The Second Affiliated Hospital of Chongqing Medical University
Corresponding Author	Jian Gao, PhD, Doctor, Doctor, Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, Yuzhong District, Chongqing 400010, China. 982213482@qq.com
Key Words	Metadherin; Hepatocellular carcinoma; Cancer stem cells; Immune infiltration
Core Tip	This study demonstrated that high metadherin (MTDH) expression is associated with poor prognosis in hepatocellular carcinoma (HCC). High MTDH expression increased the invasion and migration abilities of HCC cells and promoted stemness and self-renewal. Moreover, MTDH influenced immune cell infiltration and chemokine levels. These results provide additional evidence for the potential role of MTDH as a molecular marker for HCC.
Publish Date	2024-02-26 13:28
Citation	Wang YY, Shen MM, Gao J. Metadherin promotes stem cell phenotypes and correlated with immune infiltration in hepatocellular carcinoma. World J Gastroenterol 2024; 30(8): 901-918
URL	https://www.wjgnet.com/1007-9327/full/v30/i8/901.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i8.901

Full Article (PDF)	WJG-30-901-with-cover.pdf
Full Article (Word)	WJG-30-901.docx
The ARRIVE Guidelines	88774-The ARRIVE Guidelines-revision.pdf
Manuscript File	88774_Auto_Edited-YJP.docx
Answering Reviewers	88774-Answering reviewers.pdf
Audio Core Tip	88774-Audio core tip.mp3
Biostatistics Review Certificate	88774-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88774-Conflict-of-interest statement.pdf
Copyright License Agreement	88774-Copyright_License_Agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88774-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	88774-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	88774-Language certificate.pdf
Peer-review Report	88774-Peer-review(s).pdf
Scientific Misconduct Check	88774-Bing-Lin C-2.png
Scientific Editor Work List	88774-Scientific editor work list.pdf
CrossCheck Report	88774-CrossCheck.png
CrossCheck Report	88774-CrossCheck report.pdf