Publication Name	World Journal of Clinical Oncology
Manuscript ID	88797
Country	China

Received	2023-10-09 15:27
Peer-Review Started	2023-10-09 15:30
To Make the First Decision
Return for Revision	2023-11-23 03:44
Revised	2023-12-06 09:44
Second Decision	2024-01-08 03:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-08 07:50
Articles in Press	2024-01-08 07:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-06 07:43
Publish the Manuscript Online	2024-02-20 08:53

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Limonin inhibits the stemness of cancer stem-like cells derived from colorectal carcinoma cells potentially via blocking STAT3 signaling
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Feng Zhang, Cheng-Wei Ruan, Jun-Bo Wu, Guo-Liang Wu, Xiao-Gan Wang and Hong-Jin Chen
Funding Agency and Grant Number
Corresponding Author	Hong-Jin Chen, MD, Chief Doctor, Doctor, Full Professor, Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. 260789@njucm.edu.cn
Key Words	Limonin; Colorectal cancer; STAT3 signaling; Cancer stem-like cells; STAT3; Aldehyde dehydrogenase 1
Core Tip	Colorectal cancer (CRC) is recognized worldwide as one of the most common malignancies and frequently leads to cancer-related death and the subpopulation termed cancer stem-like cell contributes critically to recurrence and metastasis. However, therapeutic molecule or strategy targeting to this subpopulation is still largely unknown. Here, we introduce Limonin, is one of the most abundant active ingredients of Tetradium ruticarpum, as a promising molecule targeting to cancer stem-like cells for CRC therapy.
Publish Date	2024-02-20 08:53
Citation	Zhang WF, Ruan CW, Wu JB, Wu GL, Wang XG, Chen HJ. Limonin inhibits the stemness of cancer stem-like cells derived from colorectal carcinoma cells potentially via blocking STAT3 signaling. World J Clin Oncol 2024; 15(2): 317-328
URL	https://www.wjgnet.com/2218-4333/full/v15/i2/317.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i2.317

Full Article (PDF)	WJCO-15-317-with-cover.pdf
Full Article (Word)	WJCO-15-317.docx
The ARRIVE Guidelines	88797-The ARRIVE guidelines.pdf
Manuscript File	88797_Auto_Edited-JLW.docx
Answering Reviewers	88797-Answering reviewers.pdf
Audio Core Tip	88797-Audio core tip.mp3
Biostatistics Review Certificate	88797-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88797-Conflict-of-interest statement.pdf
Copyright License Agreement	88797-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	88797-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	88797-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	88797-Language certificate.pdf
Peer-review Report	88797-Peer-review(s).pdf
Scientific Misconduct Check	88797-Bing-Fan JR-2.png
Scientific Editor Work List	88797-Scientific editor work list.pdf