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2/20/2024 12:35:44 PM | Browse: 149 | Download: 441
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Received |
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2023-10-09 15:27 |
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Peer-Review Started |
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2023-10-09 15:30 |
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To Make the First Decision |
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Return for Revision |
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2023-11-23 03:44 |
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Revised |
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2023-12-06 09:44 |
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Second Decision |
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2024-01-08 03:09 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-01-08 07:50 |
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Articles in Press |
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2024-01-08 07:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-02-06 07:43 |
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Publish the Manuscript Online |
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2024-02-20 08:53 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Limonin inhibits the stemness of cancer stem-like cells derived from colorectal carcinoma cells potentially via blocking STAT3 signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Feng Zhang, Cheng-Wei Ruan, Jun-Bo Wu, Guo-Liang Wu, Xiao-Gan Wang and Hong-Jin Chen |
| Funding Agency and Grant Number |
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| Corresponding Author |
Hong-Jin Chen, MD, Chief Doctor, Doctor, Doctor, Full Professor, Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. 260789@njucm.edu.cn |
| Key Words |
Limonin; Colorectal cancer; STAT3 signaling; Cancer stem-like cells; STAT3; Aldehyde dehydrogenase 1 |
| Core Tip |
Colorectal cancer (CRC) is recognized worldwide as one of the most common malignancies and frequently leads to cancer-related death and the subpopulation termed cancer stem-like cell contributes critically to recurrence and metastasis. However, therapeutic molecule or strategy targeting to this subpopulation is still largely unknown. Here, we introduce Limonin, is one of the most abundant active ingredients of Tetradium ruticarpum, as a promising molecule targeting to cancer stem-like cells for CRC therapy. |
| Publish Date |
2024-02-20 08:53 |
| Citation |
Zhang WF, Ruan CW, Wu JB, Wu GL, Wang XG, Chen HJ. Limonin inhibits the stemness of cancer stem-like cells derived from colorectal carcinoma cells potentially via blocking STAT3 signaling. World J Clin Oncol 2024; 15(2): 317-328 |
| URL |
https://www.wjgnet.com/2218-4333/full/v15/i2/317.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v15.i2.317 |
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