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5/10/2024 1:07:43 PM | Browse: 61 | Download: 80
Publication Name World Journal of Diabetes
Manuscript ID 89061
Country China
2023-10-19 09:49
Peer-Review Started
2023-10-19 09:49
To Make the First Decision
Return for Revision
2024-01-12 05:47
2024-01-22 09:07
Second Decision
2024-03-04 07:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-03-11 06:35
Articles in Press
2024-03-11 06:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2024-04-28 08:33
Publish the Manuscript Online
2024-05-10 11:51
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Basic Study
Article Title Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation
Manuscript Source Unsolicited Manuscript
All Author List Hong Xu, Li-Bo Zhang, Yi-Yi Luo, Ling Wang, Ye-Pin Zhang, Pei-Qi Chen, Xue-Ying Ba, Jian Han and Heng Luo
Funding Agency and Grant Number
Corresponding Author Heng Luo, BMed, Doctor, Department of Ophthalmology, The People's Hospital of Chuxiong Yi Autonomous Prefecture & The Fourth Affiliated Hospital of Dali University, No. 318 Lucheng South Road, Chuxiong Yi Autonomous Prefecture 675000, Yunnan Province, China. lh18987837533@163.com
Key Words Diabetic retinopathy; Glucose transporter-1; Synaptotagmin 4; Parkin; Myelin transcription factor 1
Core Tip This study highlights the important role of synaptotagmin 4 (SYT4), which is a member of the SYTs family, in the regulation of glucose transport in retinal pigment epithelial cells during the development of diabetic retinopathy (DR). Hyperglycemia-induced overexpression of SYT4 perturbed calcium influx, resulting in the fusion of glucose transporter-1 (GLUT1) with the plasma membrane, abnormal expression of the glucose transporter GLUT1, and increased glucose uptake. Additionally, SYT4 contributed to apoptosis and inflammation, further exacerbating DR progression. This study also elucidated the molecular mechanisms by which Parkin and myelin transcription factor 1 modulate SYT4, providing new potential therapeutic targets for the clinical management of DR.
Publish Date 2024-05-10 11:51
Citation Xu H, Zhang LB, Luo YY, Wang L, Zhang YP, Chen PQ, Ba XY, Han J, Luo H. Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation. World J Diabetes 2024; 15(5): 958-976
URL https://www.wjgnet.com/1948-9358/full/v15/i5/958.htm
DOI 10.4239/wjd.v15.i5.958
Full Article (PDF) WJD-15-958-with-cover.pdf
Full Article (Word) WJD-15-958.docx
The ARRIVE Guidelines 89061-The ARRIVE guidelines.pdf
Manuscript File 89061_Auto_Edited-YJP.docx
Answering Reviewers 89061-Answering reviewers.pdf
Audio Core Tip 89061-Audio core tip.mp3
Biostatistics Review Certificate 89061-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 89061-Conflict-of-interest statement.pdf
Copyright License Agreement 89061-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 89061-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 89061-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 89061-Language certificate.pdf
Peer-review Report 89061-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 89061-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 89061-Bing-Chen YL-2.png
Scientific Editor Work List 89061-Scientific editor work list.pdf