Publication Name	World Journal of Diabetes
Manuscript ID	89061
Country	China

Received	2023-10-19 09:49
Peer-Review Started	2023-10-19 09:49
To Make the First Decision
Return for Revision	2024-01-12 05:47
Revised	2024-01-22 09:07
Second Decision	2024-03-04 07:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-11 06:35
Articles in Press	2024-03-11 06:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-28 08:33
Publish the Manuscript Online	2024-05-10 11:51

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Xu, Li-Bo Zhang, Yi-Yi Luo, Ling Wang, Ye-Pin Zhang, Pei-Qi Chen, Xue-Ying Ba, Jian Han and Heng Luo
Funding Agency and Grant Number
Corresponding Author	Heng Luo, BMed, Doctor, Department of Ophthalmology, The People's Hospital of Chuxiong Yi Autonomous Prefecture & The Fourth Affiliated Hospital of Dali University, No. 318 Lucheng South Road, Chuxiong Yi Autonomous Prefecture 675000, Yunnan Province, China. lh18987837533@163.com
Key Words	Diabetic retinopathy; Glucose transporter-1; Synaptotagmin 4; Parkin; Myelin transcription factor 1
Core Tip	This study highlights the important role of synaptotagmin 4 (SYT4), which is a member of the SYTs family, in the regulation of glucose transport in retinal pigment epithelial cells during the development of diabetic retinopathy (DR). Hyperglycemia-induced overexpression of SYT4 perturbed calcium influx, resulting in the fusion of glucose transporter-1 (GLUT1) with the plasma membrane, abnormal expression of the glucose transporter GLUT1, and increased glucose uptake. Additionally, SYT4 contributed to apoptosis and inflammation, further exacerbating DR progression. This study also elucidated the molecular mechanisms by which Parkin and myelin transcription factor 1 modulate SYT4, providing new potential therapeutic targets for the clinical management of DR.
Publish Date	2024-05-10 11:51
Citation	Xu H, Zhang LB, Luo YY, Wang L, Zhang YP, Chen PQ, Ba XY, Han J, Luo H. Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation. World J Diabetes 2024; 15(5): 958-976
URL	https://www.wjgnet.com/1948-9358/full/v15/i5/958.htm
DOI	10.4239/wjd.v15.i5.958

Full Article (PDF)	WJD-15-958-with-cover.pdf
Full Article (Word)	WJD-15-958.docx
The ARRIVE Guidelines	89061-The ARRIVE guidelines.pdf
Manuscript File	89061_Auto_Edited-YJP.docx
Answering Reviewers	89061-Answering reviewers.pdf
Audio Core Tip	89061-Audio core tip.mp3
Biostatistics Review Certificate	89061-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89061-Conflict-of-interest statement.pdf
Copyright License Agreement	89061-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	89061-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	89061-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89061-Language certificate.pdf
Peer-review Report	89061-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	89061-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	89061-Bing-Chen YL-2.png
Scientific Editor Work List	89061-Scientific editor work list.pdf
CrossCheck Report	89061-CrossCheck report.pdf