Publication Name	World Journal of Clinical Oncology
Manuscript ID	89149
Country	China

Received	2023-10-23 15:37
Peer-Review Started	2023-10-23 15:38
To Make the First Decision
Return for Revision	2023-11-23 01:21
Revised	2023-12-10 15:15
Second Decision	2023-12-28 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-12-28 07:46
Articles in Press	2023-12-28 07:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-13 12:50
Publish the Manuscript Online	2024-01-23 04:13

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Clinical and Translational Research
Article Title	Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Jie-Zhuang Huang, Jian-Di Li, Gang Chen and Rong-Quan He
Funding Agency and Grant Number	Funding Agency Grant Number Guangxi Higher Education Undergraduate Teaching Reform Project 2021JGA142 Guangxi Educational Science Planning Key Project 2022ZJY2791 Guangxi Medical University Education and Teaching Reform Project 2021XJGA02 Guangxi Zhuang Autonomous Region Health Commission Self-financed Scientific Research Project Z20201147
Corresponding Author	Rong-Quan He, MD, PhD, Doctor, Doctor, Researcher, Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road , Nanning 530021, Guangxi Zhuang Autonomous Region, China. herongquan@gxmu.edu.cn
Key Words	Hepatocellular carcinoma; Transcatheter arterial embolisation refractoriness; Weighted gene co-expression network analysis; Single-cell RNA sequencing; AUCell; CellChat
Core Tip	This is a study that explored the key genes and mechanisms related to transcatheter arterial chemoembolisation (TACE) refractoriness in hepatocellular carcinoma. Through the combination of tissue microarrays and RNA-seq with single-cell RNA sequencing, the TACE refractoriness-related genes were identified and five key genes (DLGAP5, KIF20A, ASPM, KIF11 and TPX2) associated with TACE refractoriness were revealed. The TACE refractoriness-related genes were found to mainly express in hepatocytes and embryonic stem cells. Hepatocytes providing ligands had the strongest interaction with embryonic stem cells as receptors providers.
Publish Date	2024-01-23 04:13
Citation	Huang JZ, Li JD, Chen G, He RQ. Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma. World J Clin Oncol 2024; 15(1): 62-88
URL	https://www.wjgnet.com/2218-4333/full/v15/i1/62.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i1.62

Full Article (PDF)	WJCO-15-62-with-cover.pdf
Full Article (Word)	WJCO-15-62.docx
Manuscript File	89149_Auto_Edited-LJH-YJP.docx
Answering Reviewers	89149-Answering reviewers.pdf
Audio Core Tip	89149-Audio core tip.mp3
Biostatistics Review Certificate	89149-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89149-Conflict-of-interest statement.pdf
Copyright License Agreement	89149-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89149-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	89149-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89149-Language certificate.pdf
Supplementary Material	89149-Supplementary material.pdf
Peer-review Report	89149-Peer-review(s).pdf
Scientific Misconduct Check	89149-Bing-Liu JH-2.png
Scientific Misconduct Check	89149-CrossCheck.png
Scientific Editor Work List	89149-Scientific editor work list.pdf
CrossCheck Report	89149-CrossCheck report.pdf