Publication Name	World Journal of Gastroenterology
Manuscript ID	89261
Country	China

Received	2023-10-25 16:37
Peer-Review Started	2023-10-25 16:39
First Decision by Editorial Office Director	2023-11-12 03:12
Return for Revision	2023-11-12 03:12
Revised	2023-11-23 05:10
Publication Fee Transferred
Second Decision by Editor	2023-12-07 10:00
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2023-12-14 05:30
Articles in Press	2023-12-14 05:30
Edit the Manuscript by Language Editor	2023-12-19 19:34
Typeset the Manuscript	2024-01-08 02:04
Publish the Manuscript Online	2024-01-12 08:02

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Retrospective Study
Article Title	Association of tumor budding with clinicopathological features and prognostic value in stage III-IV colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yue-Hao Luo, Zhe-Cheng Yan, Jia-Ying Liu, Xin-Yi Li, Ming Yang, Jun Fan, Bo Huang, Cheng-Gong Ma, Xiao-Na Chang and Xiu Nie
Funding Agency and Grant Number	Funding Agency Grant Number National Key R&D Program of China 2022YFF1203300
Corresponding Author	Xiu Nie, MD, Professor, Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. niexiuyishi@126.com
Key Words	Tumor budding; Tumor infiltrating lymphocytes; Colorectal cancer; Survival analysis; Prognosis
Core Tip	This study included a substantial number of 547 colorectal cancer (CRC) patients. Tumor budding (TB) was evaluated independently by two pathologists and re-evaluated by the third pathologist when the results were inconsistent, ensuring a high level of reliability in the TB assessment. Furthermore, the 2016 International Tumor Budding Consensus Conference recommendations were followed to evaluate TB specifically in patients with stage III-IV CRC, thereby investigating its impact on patient prognosis. TB has an independent predictive prognostic value for progression free survival and overall survival in patients with stage III-IV CRC. It is recommended to complete the TB report of stage III-IV CRC cases in the standardized pathological report to further refine risk stratification.
Publish Date	2024-01-12 08:02
Citation	Luo YH, Yan ZC, Liu JY, Li XY, Yang M, Fan J, Huang B, Ma CG, Chang XN, Nie X. Association of tumor budding with clinicopathological features and prognostic value in stage III-IV colorectal cancer. World J Gastroenterol 2023; 30(2): 158-169
URL	https://www.wjgnet.com/1007-9327/full/v30/i2/158.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i2.158

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