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3/12/2024 12:31:14 PM | Browse: 184 | Download: 415
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Received |
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2023-10-26 09:04 |
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Peer-Review Started |
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2023-10-26 09:05 |
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To Make the First Decision |
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Return for Revision |
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2023-12-31 07:15 |
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Revised |
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2024-01-04 07:42 |
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Second Decision |
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2024-01-31 02:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-01-31 06:00 |
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Articles in Press |
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2024-01-31 06:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-02-28 01:04 |
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Publish the Manuscript Online |
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2024-03-12 10:04 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Jun Lin and Ye-Cai Lu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Anhui Provincial Health Research Project |
AHWJ2022c036 |
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| Corresponding Author |
Ye-Cai Lu, MD, Professor, Department of Gastrointestinal Surgery, Chaohu Hospital of Anhui Medical University, No. 64 Chaohu North Road, Chaohu 238000, Anhui Province, China. 13965691202@163.com |
| Key Words |
Ubiquitin-specific protease 21; ZEB1; Stemness; Colorectal cancer |
| Core Tip |
Ubiquitin-specific protease 21 (USP21) and ZEB1 had been discovered to exhibit higher expressions in colorectal cancer (CRC) tissues and cells, and result into poor prognosis. USP21 contributed to the stability of ZEB1 through modulating ubiquitination level. Our findings proved that USP21 promoted tumorigenicity and stemness of CRC by deubiquitinating and stabilizing ZEB1. Moreover, it was uncovered that USP21/ZEB1 axis aggravated tumor growth in vivo. |
| Publish Date |
2024-03-12 10:04 |
| Citation |
Lin JJ, Lu YC. Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1. World J Gastrointest Oncol 2024; 16(3): 1006-1018 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i3/1006.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i3.1006 |
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