| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qi-Long Wu, Xiao-Ting Fang, Xin-Xin Wan, Qing-Yong Ding, Yan-Jun Zhang, Ling Ji, Yong-Liang Lou and Xiang Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Discipline of Zhejiang Province in Medical Technology (First Class, Category A) |
|
| Health Project of the Science and Technology Department of Wenzhou |
Y20220029 |
|
| Corresponding Author |
Xiang Li, PhD, Associate Professor, Deputy Director, Postdoc, Department of Health Inspection and Quarantine, School of Laboratory Medicine and Life Sciences, Institute of One Health, Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Medical Genetics, Ministry of Education, No. 1 Qiuzhen Road, Wenzhou 325035, Zhejiang Province, China. yhx2008@163.com |
| Key Words |
Colorectal cancer; Fusobacterium nucleatum; Butyric acid; Gut microbiota; Adenosine monophosphate-activated protein kinase signal pathway |
| Core Tip |
In this research, we unravel the mechanism of Fusobacterium nucleatum (F. nucleatum) in the progression of colorectal cancer (CRC), focusing on the interplay between intestinal flora and metabolism. Our results reveal that F. nucleatum suppresses the production of the short-chain fatty acid, butyric acid. We discovered that sodium butyrate impairs mitochondrial function and impedes the cell cycle in CRC cells. Furthermore, the study highlights that both sodium butyrate and F. nucleatum orchestrate the proliferation of CRC cells via the adenosine monophosphate-activated protein kinase signaling pathway. These insights may enhance our understanding of CRC pathogenesis and aid in the development of more effective treatment strategies. |
| Publish Date |
2024-04-12 16:45 |
| Citation |
Wu QL, Fang XT, Wan XX, Ding QY, Zhang YJ, Ji L, Lou YL, Li X. Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer. World J Gastroenterol 2024; 30(14): 2018-2037 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i14/2018.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i14.2018 |
