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3/15/2024 11:10:23 AM | Browse: 235 | Download: 541
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Received |
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2023-11-08 17:31 |
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Peer-Review Started |
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2023-11-08 17:32 |
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To Make the First Decision |
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Return for Revision |
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2023-11-29 07:36 |
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Revised |
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2023-12-04 12:36 |
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Second Decision |
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2023-12-22 02:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-12-29 05:01 |
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Articles in Press |
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2023-12-29 05:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-03-12 07:48 |
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Publish the Manuscript Online |
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2024-03-15 08:06 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Current status and future perspectives on stem cell transplantation for spinal cord injury
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Edoardo Agosti, Marco Zeppieri, Andrea Pagnoni, Marco Maria Fontanella, Alessandro Fiorindi, Tamara Ius and Pier Paolo Panciani |
| Funding Agency and Grant Number |
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| Corresponding Author |
Marco Zeppieri, BSc, MD, PhD, Doctor, Doctor, Department of Ophthalmology, University Hospital of Udine, p.le S. Maria della Misericordia 15, Udine 33100, Italy. markzeppieri@hotmail.com |
| Key Words |
Spinal cord injury; Stem cell therapy; Adverse events; Functional outcomes; Systematic review |
| Core Tip |
In the context of spinal cord injury (SCI) treatment, stem cell-based therapies exhibit promise, as demonstrated in this systematic review of 66 studies. However, the research reveals potential adverse events and limitations, emphasizing the importance of optimizing transplantation conditions, cautious clinical implementation, a deeper understanding of SCI pathophysiology, and addressing ethical, tumorigenicity, immunogenicity, and immunotoxicity concerns before a gradual and careful adoption of stem cell therapy in clinical practice. This underscores the need for further research to ensure the safety and effectiveness of these therapies for SCI patients, while acknowledging their potential for improving functional outcomes. |
| Publish Date |
2024-03-15 08:06 |
| Citation |
Agosti E, Zeppieri M, Pagnoni A, Fontanella MM, Fiorindi A, Ius T, Panciani PP. Current status and future perspectives on stem cell transplantation for spinal cord injury. World J Transplant 2023; In press |
| URL |
https://www.wjgnet.com/2220-3230/full/v14/i1/89674.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v14.i1.89674 |
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