Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	90123
Country	China

Received	2023-11-24 15:24
Peer-Review Started	2023-11-24 15:25
To Make the First Decision
Return for Revision	2024-01-12 09:20
Revised	2024-01-16 06:56
Second Decision	2024-02-04 03:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-02-04 05:15
Articles in Press	2024-02-04 05:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-25 08:40
Publish the Manuscript Online	2024-04-11 02:23

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Yong Pan, Yi-Ru Zhang, Ling-Yun Wang, Li-Na Wu, Ying-Qiu Ma, Zhou Fang and Shi-Bo Li
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Province Major Science and Technology Project WKJ-ZJ-2329
Corresponding Author	Shi-Bo Li, N/A, Doctor, Doctor, Department of Infectious Disease, Zhoushan Hospital, Wenzhou Medical University, No. 739 Dingshen Road, Zhoushan 316021, Zhejiang Province, China. lsb0398@126.com
Key Words	Hepatocellular carcinoma; Competitive endogenous RNA; Molecular mechanism; Prognosis; Biomarker
Core Tip	In this study, the mutation landscape, and molecular biological mechanisms of cyclin dependent kinase inhibitor 2A (CDKN2A) in hepatocellular carcinoma (HCC) was first explored, and a CDKN2A-related competitive endogenous RNA axis was constructed. We identified growth arrest specific 5 as an independent prognostic biomarker and established a prognostic nomogram model for HCC. Moreover, we analyzed its methylation level, immune infiltration, and targeted agents, which might be an independent prognostic biomarker and therapeutic target in HCC.
Publish Date	2024-04-11 02:23
Citation	Pan Y, Zhang YR, Wang LY, Wu LN, Ma YQ, Fang Z, Li SB. Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma. World J Gastrointest Oncol 2024; 16(4): 1514-1531
URL	https://www.wjgnet.com/1948-5204/full/v16/i4/1514.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i4.1514

Full Article (PDF)	WJGO-16-1514-with-cover.pdf
Manuscript File	90123_Auto_Edited-YJP.docx
Answering Reviewers	90123-Answering reviewers.pdf
Audio Core Tip	90123-Audio core tip.mp3
Biostatistics Review Certificate	90123-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90123-Conflict-of-interest statement.pdf
Copyright License Agreement	90123-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90123-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	90123-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	90123-Language certificate.pdf
Supplementary Material	90123-Supplementary material.pdf
Peer-review Report	90123-Peer-review(s).pdf
Scientific Misconduct Check	90123-Bing-Chen YL-2.png
Scientific Editor Work List	90123-Scientific editor work list.pdf
CrossCheck Report	90123-CrossCheck report.pdf