Publication Name	World Journal of Gastroenterology
Manuscript ID	90126
Country	Greece

Received	2023-11-23 19:04
Peer-Review Started	2023-11-23 19:05
To Make the First Decision
Return for Revision	2024-01-05 05:47
Revised	2024-01-13 17:10
Second Decision	2024-01-30 02:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-30 06:54
Articles in Press	2024-01-30 06:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-05 00:07
Publish the Manuscript Online	2024-02-26 13:28

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Editorial
Article Title	Immune signature of small bowel adenocarcinoma and the role of tumor microenvironment
Manuscript Source	Invited Manuscript
All Author List	Grigorios Christodoulidis, Marina Nektaria Kouliou and Konstantinos Eleftherios Koumarelas
Funding Agency and Grant Number
Corresponding Author	Grigorios Christodoulidis, PhD, Doctor, Editor-in-Chief, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. gregsurg09@gmail.com
Key Words	Programmed cell death 1; Programmed cell death-ligand 1; Programmed death ligand; Small bowel adenocarcinoma; Tumor infiltrating lymphocytes; Tumor microenvironment; Microsatellite instability
Core Tip	Small bowel adenocarcinoma (SBA) is an uncommon gastrointestinal tumor, accounting for fewer than 3% of all cases, even though it constitutes 95% of the gastrointestinal tract. SBA, which is mostly located in the duodenum, typically goes undetected for a long period of time, resulting to a late-stage discovery and a dismal prognosis. The immunological response, consisting of CD4+ and CD8+ T-lymphocytes, is critical in determining the prognosis. Programmed cell death 1/programmed cell death-ligand 1 (PD-L1) pathway, which is known to be involved in immune evasion in cancer, is implicated in SBA, with PD-L1 expression to a variety of prognostic consequences. The complicated interaction of immunological components, including as TILs and regulatory T cells, emphasizes the complexities of SBA.
Publish Date	2024-02-26 13:28
Citation	Christodoulidis G, Kouliou MN, Koumarelas KE. Immune signature of small bowel adenocarcinoma and the role of tumor microenvironment. World J Gastroenterol 2024; 30(8): 794-798
URL	https://www.wjgnet.com/1007-9327/full/v30/i8/794.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i8.794

Full Article (PDF)	WJG-30-794-with-cover.pdf
Full Article (Word)	WJG-30-794.docx
Manuscript File	90126_Auto_Edited-YJP.docx
Answering Reviewers	90126-Answering reviewers.pdf
Audio Core Tip	90126-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	90126-Conflict-of-interest statement.pdf
Copyright License Agreement	90126-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	90126-Language certificate.pdf
Peer-review Report	90126-Peer-review(s).pdf
Scientific Misconduct Check	90126-Bing-Li L-2.png
Scientific Editor Work List	90126-Scientific editor work list.pdf