Publication Name	World Journal of Transplantation
Manuscript ID	90194
Country	Italy

Received	2023-11-26 14:51
Peer-Review Started	2023-11-26 14:52
To Make the First Decision
Return for Revision	2023-12-17 02:18
Revised	2023-12-22 01:09
Second Decision	2023-12-29 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-12-29 04:55
Articles in Press	2023-12-29 04:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-12 07:34
Publish the Manuscript Online	2024-03-15 08:06

ISSN	2220-3230 (online)
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Category	Transplantation
Manuscript Type	Minireviews
Article Title	Update on the reciprocal interference between immunosuppressive therapy and gut microbiota after kidney transplantation
Manuscript Source	Invited Manuscript
All Author List	Maurizio Salvadori and Giuseppina Rosso
Funding Agency and Grant Number
Corresponding Author	Maurizio Salvadori, MD, Professor, Department of Renal Transplantation, Careggi University Hospital, 18 Viale Pieraccini, Florence 50139, Tuscany, Italy. maurizio.salvadori1@gmail.com
Key Words	Immunosuppressive therapy; Kidney transplantation; Gut microbiota; Dysbiosis; Pathobionts; Graft outcomes
Core Tip	Gut dysbiosis frequently occurs in the first period after kidney transplantation. Among the different causes, immunosuppressive drugs play a relevant role. There is a reciprocal effect between immunosuppressive drugs and the gut microbiota. Indeed, immunosuppressive drugs may change the gut microbiota composition causing dysbiosis as related side effects as rejection and infections. In contrast, the gut microbiota may alter the pharmacokinetic of immunosuppressive drugs determining modification in their metabolism and favoring the presence of substances with lower or higher immunosuppressant effect with respect to the original compound. Physicians should pay particular attention to these possibilities and carefully control both changes in the gut microbiota and the correct level of immunosuppressive drugs.
Publish Date	2024-03-15 08:06
Citation	Salvadori M, Rosso G. Update on the reciprocal interference between immunosuppressive therapy and gut microbiota after kidney transplantation. World J Transplant 2023; In press
URL	https://www.wjgnet.com/2220-3230/full/v14/i1/90194.htm
DOI	https://dx.doi.org/10.5500/wjt.v14.i1.90194

Full Article (PDF)	WJT-14-90194-with-cover.pdf
Manuscript File	90194_Auto_Edited-YJP.docx
Answering Reviewers	90194-Answering reviewers.pdf
Audio Core Tip	90194-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	90194-Conflict-of-interest statement.pdf
Copyright License Agreement	90194-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	90194-Language certificate.pdf
Peer-review Report	90194-Peer-review(s).pdf
Scientific Misconduct Check	90194-Bing-Chen YL-2.png
Scientific Editor Work List	90194-Scientific editor work list.pdf