Publication Name	World Journal of Medical Genetics
Manuscript ID	9023
Country	Russia

Received	2014-01-16 13:58
Peer-Review Started	2014-01-17 16:14
First Decision by Editorial Office Director
Return for Revision	2014-03-18 14:02
Revised	2014-04-11 18:22
Publication Fee Transferred
Second Decision by Editor	2014-08-31 16:57
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-08-31 17:12
Articles in Press	2014-08-31 17:13
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-14 17:37
Publish the Manuscript Online	2014-11-18 11:54

ISSN	2220-3184 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Review
Article Title	Genome variation in the trophoblast cell lifespan: Diploidy, polyteny, depolytenization, genome segregation
Manuscript Source	Invited Manuscript
All Author List	Tatiana G Zybina and Eugenia V Zybina
Funding Agency and Grant Number	Funding Agency Grant Number Program “Molecular and Cell Biology” of the Russian Academy of Sciences
Corresponding Author	Tatiana G Zybina, ScD, Laboratory of Cell Pathology, Institute of Cytology, Russian Academy of Sciences, Tikhoretsky ave., 4, 194064 St.-Petersburg, Russian Federation. zybina@mail.cytspb.rssi.ru
Key Words	Cell cycle; Endocycle; Polyploidy; Genome; Aneuploidy; Trophoblast; Placenta
Core Tip	In rodent placenta, differentiation of secondary trophoblast giant cells give an example of the irreversible endoreduplication (up to 1024c and higher) that, however, results in formation of low-ploid subcellular compartments uncapable of mitotic proliferation. In the mammalian species with lengthy period of pregnancy, more diverse genome changes may be useful to select a more specific response to stressful factors that may appear occasionally during months of intrauterine development.
Publish Date	2014-11-18 11:54
Citation	Zybina TG, Zybina EV. Genome variation in the trophoblast cell lifespan: Diploidy, polyteny, depolytenization, genome segregation. World J Med Genet 2014; 4(4): 77-93
URL	http://www.wjgnet.com/2220-3184/full/v4/i4/77.htm
DOI	http://dx.doi.org/10.5496/wjmg.v4.i4.77

Full Article (PDF)	WJMG-4-77.pdf
Full Article (Word)	WJMG-4-77.doc
Manuscript File	9023-Review.doc
Answering Reviewers	9023-Answering reviewers.pdf
Copyright License Agreement	9023-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9023-Language certificate.pdf
Peer-review Report	9023-Peer review(s).pdf
Scientific Misconduct Check	9023-CroccCheck.jpg
Scientific Editor Work List	9023-Scientific editor work list.pdf