Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	90319
Country	China

Received	2023-11-30 03:32
Peer-Review Started	2023-11-30 03:32
To Make the First Decision
Return for Revision	2024-02-20 01:53
Revised	2024-02-26 15:07
Second Decision	2024-04-01 06:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-01 08:35
Articles in Press	2024-04-01 08:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-23 02:16
Publish the Manuscript Online	2024-05-09 13:59

ISSN	1948-5204 (online)
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor
Manuscript Source	Invited Manuscript
All Author List	Jing Zhou, Mei-Ying Zhang, Ai-Ai Gao, Cheng Zhu, Tao He, James G Herman and Ming-Zhou Guo
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Program of China 2018YFA0208902 National Science Foundation of China U160428,182272632,81672318 Beijing Science Foundation of China 7171008 Youth Innovation Science Foundation of Chinese PLA general hospital 22QNCZ027
Corresponding Author	Ming-Zhou Guo, MD, PhD, Professor, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China. guomingzhou@301hospital.org
Key Words	Schlafen-11; Esophageal squamous cell carcinoma; DNA methylation; Synthetic lethality; AZD0156
Core Tip	Targeting DNA damage repair (DDR) is a novel strategy for cancer therapy. Epigenetic-based synthetic lethality studies have been conducted recently. Schlafen-11 (SLFN11) has been reported to sensitize cancer cells by involving DDR. However, the detailed regulatory network in DDR remains controversial. This study explored the mechanism of SLFN11 in DDR, and further investigated the synthetic lethal efficiency of epigenetic silencing SLFN11 and ATM inhibitor. The results demonstrated that SLFN11 activated non-homologous end-joining and ATR/CHK1, while inhibiting the ATM/CHK2 signaling pathway. Epigenetic silencing SLFN11 sensitized esophageal cancer cells to ATM inhibitor both in vitro and in vivo.
Publish Date	2024-05-09 13:59
Citation	Zhou J, Zhang MY, Gao AA, Zhu C, He T, Herman JG, Guo MZ. Epigenetic silencing Schlafen-11 sensitizes esophageal cancer to ATM inhibitor. World J Gastrointest Oncol 2024; 16(5): 2060-2073
URL	https://www.wjgnet.com/1948-5204/full/v16/i5/2060.htm
DOI	10.4251/wjgo.v16.i5.2060

Full Article (PDF)	WJGO-16-2060-with-cover.pdf
The ARRIVE Guidelines	90319-The ARRIVE guidelines.pdf
Manuscript File	90319_Auto_Edited-YJP.docx
Answering Reviewers	90319-Answering reviewers.pdf
Audio Core Tip	90319-Audio core tip.mp3
Biostatistics Review Certificate	90319-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90319-Conflict-of-interest statement.pdf
Copyright License Agreement	90319-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90319-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	90319-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	90319-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	90319-Language certificate.pdf
Peer-review Report	90319-Peer-review(s).pdf
Scientific Misconduct Check	90319-Bing-Chen YL-2.png
Scientific Editor Work List	90319-Scientific editor work list.pdf
CrossCheck Report	90319-CrossCheck report.pdf