Publication Name	World Journal of Gastroenterology
Manuscript ID	90398
Country	United States

Received	2023-12-05 03:52
Peer-Review Started	2023-12-05 03:52
To Make the First Decision
Return for Revision	2024-01-27 06:25
Revised	2024-02-22 14:37
Second Decision	2024-03-13 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-13 06:25
Articles in Press	2024-03-13 06:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-28 01:21
Publish the Manuscript Online	2024-04-03 07:21

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer: Unravelling challenges and future directions
Manuscript Source	Unsolicited Manuscript
All Author List	Samantha Sharma, Naresh Singh, Anita Ahmed Turk, Isabella Wan, Akshay Guttikonda, Julia Lily Dong, Xinna Zhang and Mateusz Opyrchal
Funding Agency and Grant Number	Funding Agency Grant Number IU Simon Comprehensive Cancer Center grant 5P30CA082709-24
Corresponding Author	Samantha Sharma, PhD, Assistant Professor, Department of Medical and Molecular Genetics, Indiana University School of Medicine, 980 W Walnut St, R3.C260, Indianapolis, IN 46202, United States. samshar@iu.edu
Key Words	Colorectal cancer; Immune checkpoint inhibitors; Clinical trials; Immunotherapy; Microsatellite instability; Microsatellite stability; DNA mismatch repair
Core Tip	Colorectal cancer (CRC) often eludes early detection, limiting the efficacy of existing chemotherapy and targeted therapies. This article delves into the realm of immune checkpoint inhibitors in CRC, dissecting their mechanisms and outcomes through a comprehensive review of clinical trials. It sheds light on the underlying rationale, challenges faced, and potential strategies to improve prognosis and trial success in this critical domain. Notably, while microsatellite instability-high CRC exhibits heightened responsiveness to checkpoint inhibitors, the article underscores potential breakthroughs in treating microsatellite stable CRC-the predominant cases-providing insights into bettering prognosis and trial outcomes in CRC treatment.
Publish Date	2024-04-03 07:21
Citation	Sharma S, Singh N, Turk AA, Wan I, Guttikonda A, Dong JL, Zhang X, Opyrchal M. Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer: Unravelling challenges and future directions. World J Gastroenterol 2024; 30(13): 1815-1835
URL	https://www.wjgnet.com/1007-9327/full/v30/i13/1815.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i13.1815

Full Article (PDF)	WJG-30-1815-with-cover.pdf
Manuscript File	90398_Auto_Edited-YJP.docx
Answering Reviewers	90398-Answering reviewers.pdf
Audio Core Tip	90398-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	90398-Conflict-of-interest statement.pdf
Copyright License Agreement	90398-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90398-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	90398-Language certificate.pdf
Peer-review Report	90398-Peer-review(s).pdf
Scientific Misconduct Check	90398-Bing-Lin C-2.png
Scientific Editor Work List	90398-Scientific editor work list.pdf
CrossCheck Report	90398-CrossCheck.png
CrossCheck Report	90398-CrossCheck report.pdf