| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Huang Chen, Rui-Ying Jiang, Zhan Hua, Xiao-Wei Wang, Xiao-Li Shi, Ye Wang, Qian-Qian Feng, Jie Luo, Wu Ning, Yan-Fen Shi, Da-Kui Zhang, Bei Wang, Jian-Zheng Jie and Ding-Rong Zhong |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National High Level Hospital Clinical Research Funding |
2023-NHLHCRF-YYPPLC-TJ-03 |
|
| Corresponding Author |
Ding-Rong Zhong, MD, Chief Doctor, Department of Pathology, China-Japan Friendship Hospital, No. 2 Yinghuayuan, East Street, Chaoyang District, Beijing 100029, China. 748803069@qq.com |
| Key Words |
Colorectal cancer; Deficient mismatch repair; Microsatellite instability; Gene mutation; Comprehensive analysis |
| Core Tip |
This study presents a comprehensive analysis of KRAS, NRAS, BRAF, PIK3CA mutations, and mismatch repair (MMR)/microsatellite instability status in 2271 Chinese patients with colorectal cancer (CRC). Key findings include mutation frequencies, their association with clinicopathological characteristics, and the influence of MMR deficiency. These findings have significant implications for the clinical management of CRC, providing a foundation for personalized therapy and precision medicine in CRC. |
| Publish Date |
2024-06-15 02:49 |
| Citation |
<p>Chen H, Jiang RY, Hua Z, Wang XW, Shi XL, Wang Y, Feng QQ, Luo J, Ning W, Shi YF, Zhang DK, Wang B, Jie JZ, Zhong DR. Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients. <i>World J Gastrointest Oncol</i> 2024; 16(6): 2673-2682</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i6/2673.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i6.2673 |
