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2/5/2024 12:42:30 PM | Browse: 123 | Download: 71
Publication Name World Journal of Gastroenterology
Manuscript ID 90452
Country/Territory China
Received
2023-12-04 13:59
Peer-Review Started
2023-12-04 13:59
To Make the First Decision
Return for Revision
2023-12-08 05:32
Revised
2023-12-20 20:25
Second Decision
2024-01-16 02:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-01-16 04:41
Articles in Press
2024-01-16 04:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2024-01-30 13:37
Publish the Manuscript Online
2024-02-05 12:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Basic Study
Article Title Role of deubiquitinase JOSD2 in the pathogenesis of esophageal squamous cell carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Wen-Peng Wang, Dan Shi, Duo Yun, Jun Hu, Jie-Fu Wang, Jia Liu, Yan-Peng Yang, Ming-Rui Li, Jun-Feng Wang and Da-Lu Kong
Funding Agency and Grant Number
Funding Agency Grant Number
Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-009A
Tianjin Medical University Cancer Hospital National Natural Science Foundation Cultivation Program 220108
National Natural Science Foundation of China 82373134
Science and Technology Development Fund of Tianjin Education Commission for Higher Education 2022KJ228
Chinese Anti-Cancer Association-Heng Rui Anti-angiogenesis Targeted Tumor Research Fund 2021001045
Scientific Research Translational Foundation of Wenzhou Safety (Emergency) Institute of Tianjin University TJUWYY2022025
Corresponding Author Da-Lu Kong, BMed, Chief Physician, Director, Doctor, Department of Colorectal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Huanhuxi Road, Hexi District, Tianjin 300060, China. kongdalu2021@126.com
Key Words Esophageal squamous cell carcinoma; JOSD2; Ubiquitination; Biomarker; Targeted therapy; Drug resistance
Core Tip JOSD2, a deubiquitinating enzyme, is a key player in the aggressive pathogenesis of esophageal squamous cell carcinoma (ESCC). Elevated JOSD2 expression in ESCC tissues is associated with poor prognosis. Functional analyses, including in vivo xenograft assays, highlight JOSD2's role in promoting tumor proliferation and drug resistance. Mechanistically, JOSD2 activates the MAPK/ERK and PI3K/AKT signaling pathways. Mass spectrometry identified key interacting proteins, including USP47, IGKV2D-29, HSP90AB1, and PRMT5. This study underscores the potential role of JOSD2 as a therapeutic target in ESCC.
Publish Date 2024-02-05 12:08
Citation Wang WP, Shi D, Yun D, Hu J, Wang JF, Liu J, Yang YP, Li MR, Wang JF, Kong DL. Role of deubiquitinase JOSD2 in the pathogenesis of esophageal squamous cell carcinoma. World J Gastroenterol 2024; 30(6): 565-578
URL https://www.wjgnet.com/1007-9327/full/v30/i6/565.htm
DOI https://dx.doi.org/10.3748/wjg.v30.i6.565
Full Article (PDF) WJG-30-565-with-cover.pdf
Full Article (Word) WJG-30-565.docx
The ARRIVE Guidelines 90452-The ARRIVE guidelines.pdf
Manuscript File 90452_Auto_Edited-YJP.docx
Answering Reviewers 90452-Answering reviewers.pdf
Audio Core Tip 90452-Audio core tip.mp3
Biostatistics Review Certificate 90452-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 90452-Conflict-of-interest statement.pdf
Copyright License Agreement 90452-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 90452-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 90452-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 90452-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 90452-Language certificate.pdf
Supplementary Material 90452-Supplementary material.zip
Peer-review Report 90452-Peer-review(s).pdf
Scientific Misconduct Check 90452-Bing-Fan JR-2.png
Scientific Editor Work List 90452-Scientific editor work list.pdf