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1/26/2024 12:59:06 PM | Browse: 81 | Download: 265
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Received |
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2023-12-12 03:50 |
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Peer-Review Started |
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2023-12-12 03:50 |
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To Make the First Decision |
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Return for Revision |
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2023-12-19 03:10 |
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Revised |
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2023-12-21 10:44 |
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Second Decision |
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2024-01-03 03:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2024-01-03 05:24 |
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Articles in Press |
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2024-01-03 05:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-01-20 15:03 |
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Publish the Manuscript Online |
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2024-01-26 07:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Amlodipine inhibits the proliferation and migration of esophageal carcinoma cells through the induction of endoplasmic reticulum stress
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Min Chen, Wen-Qian Yang, Cheng-Wei Gu, Ying-Ying Fan, Yu-Zhen Liu and Bao-Sheng Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Medical Scientific and Technological Project of Henan Province |
SBGJ202102188 |
| Henan Provincial Medical Science and Technology Project |
LHJ20221012 |
| Key Project of Science and Technology of Xinxiang |
GG2020027 |
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| Corresponding Author |
Bao-Sheng Zhao, BMed, Chief Physician, Professor, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui 453100, Henan Province, China. drbszhao@xxmu.edu.cn |
| Key Words |
L-type calcium channel; Amlodipine; Esophageal cancer; Autophagy; Endoplasmic reticulum stress |
| Core Tip |
L-type calcium channel blockers have been shown to inhibit the growth of various tumors. We observed a higher expression of the L-type calcium channel Cav1.3 in esophageal cancer (EC) tissue than in paracancerous tissues. Subsequently, we confirmed that amlodipine inhibited the development of EC both in vivo and in vitro. Finally, we established that this inhibitory effect is related to the activation of endoplasmic reticulum stress. |
| Publish Date |
2024-01-26 07:56 |
| Citation |
Chen YM, Yang WQ, Gu CW, Fan YY, Liu YZ, Zhao BS. Amlodipine inhibits the proliferation and migration of esophageal carcinoma cells through the induction of endoplasmic reticulum stress. World J Gastroenterol 2024; 30(4): 367-380 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i4/367.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i4.367 |
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