Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	90893
Country	Pakistan

Received	2023-12-16 16:33
Peer-Review Started	2023-12-16 16:33
To Make the First Decision
Return for Revision	2024-01-31 18:22
Revised	2024-02-13 18:43
Second Decision	2024-03-26 01:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-26 04:44
Articles in Press	2024-03-26 04:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-15 02:49
Publish the Manuscript Online	2024-04-19 03:18

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Des-gamma-carboxy prothrombin and alpha-fetoprotein levels as biomarkers for hepatocellular carcinoma and their correlation with radiological characteristics
Manuscript Source	Invited Manuscript
All Author List	Muhammad Ali Qadeer, Zaigham Abbas, Shaima Amjad, Bushra Shahid, Abeer Altaf and Mehreen Siyal
Funding Agency and Grant Number
Corresponding Author	Zaigham Abbas, AGAF, FACG, FACP, FCPS, FRCP, MBBS, Professor, Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Street Address, Karachi 75600, Pakistan. drzabbas@gmail.com
Key Words	Des-gamma-carboxy prothrombin; Protein induced by vitamin K absence-II; Cirrhosis; Alpha-fetoprotein; Biomarkers; Hepatocellular carcinoma; Portal vein thrombus
Core Tip	In this prospective study, the performance of des-gamma-carboxy prothrombin (DCP) relative to alpha-fetoprotein (AFP) was assessed in 202 patients diagnosed with hepatocellular carcinoma (HCC). DCP, when used as a standalone marker, exhibited superior diagnostic performance compared to AFP. Combining both tumor markers increased the overall detection rate of HCC, particularly in tumors less than 2 cm in length. Nevertheless, it is recommended that, if a single tumor marker is used, DCP is preferred. The role of DCP as a screening biomarker should be incorporated into the HCC guidelines.
Publish Date	2024-04-19 03:18
Citation	Qadeer MA, Abbas Z, Amjad S, Shahid B, Altaf A, Siyal M. Des-gamma-carboxy prothrombin and alpha-fetoprotein levels as biomarkers for hepatocellular carcinoma and their correlation with radiological characteristics. World J Gastrointest Pathophysiol 2024; 15(1): 90893
URL	https://www.wjgnet.com/2150-5330/full/v15/i1/90893.htm
DOI	https://dx.doi.org/10.4291/wjgp.v15.i1.90893

Full Article (PDF)	WJGP-15-90893-with-cover.pdf
STROBE Statement	90893-STROBE statement.pdf
Manuscript File	90893_Auto_Edited-YJP.docx
Answering Reviewers	90893-Answering reviewers.pdf
Audio Core Tip	90893-Audio core tip.m4a
Biostatistics Review Certificate	90893-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90893-Conflict-of-interest statement.pdf
Copyright License Agreement	90893-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	90893-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	90893-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	90893-Language certificate.pdf
Peer-review Report	90893-Peer-review(s).pdf
Scientific Misconduct Check	90893-Bing-Chen YL-2.png
Scientific Editor Work List	90893-Scientific editor work list.pdf
CrossCheck Report	90893-CrossCheck report.pdf