Publication Name	World Journal of Diabetes
Manuscript ID	90940
Country	China

Received	2023-12-19 01:26
Peer-Review Started	2023-12-19 01:26
To Make the First Decision
Return for Revision	2024-04-29 17:35
Revised	2024-05-09 12:57
Second Decision	2024-06-11 06:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-02 08:22
Articles in Press	2024-09-02 08:22
Publication Fee Transferred	2024-09-09 03:00
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-20 06:02
Publish the Manuscript Online	2024-09-26 08:51

ISSN	1948-9358 (online)
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Category	Medicine, Research & Experimental
Manuscript Type	Clinical and Translational Research
Article Title	Identification of immune feature genes and intercellular profiles in diabetic cardiomyopathy
Manuscript Source	Unsolicited Manuscript
All Author List	Ze-Qun Zheng, Di-Hui Cai and Yong-Fei Song
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82300347 Natural Science Foundation of Ningbo 2021J296 Science Foundation of Lihuili Hospital 202122ZD004
Corresponding Author	Yong-Fei Song, MD, Assistant Professor, Researcher, Ningbo Institute of Innovation for Combined Medicine and Engineering, The Affiliated Lihuili Hospital of Ningbo University, No. 378 Dongqing Road, Yinzhou District, Ningbo 315040, Zhejiang Province, China. songyongfei1@gmail.com
Key Words	Diabetic cardiomyopathy; Immune feature genes; Proenkephalin; Retinol binding protein 7; Immune cell infiltration; Intercellular communication
Core Tip	In this study, we utilized bulk RNA sequencing (RNA-seq) data and machine learning techniques to identify and validate four immune feature genes associated with diabetic cardiomyopathy (DCM). Notably, retinol binding protein 7 and proenkephalin showed significantly elevated expression in cardiomyocytes and interstitial cells in DCM, as confirmed by single-cell RNA-seq and molecular experiments, highlighting their robust diagnostic potential. Furthermore, single-cell RNA-seq data revealed abnormal cellular phenotype transformations and communications in DCM, particularly between fibroblasts and macrophages.
Publish Date	2024-09-26 08:51
Citation	<p>Zheng ZQ, Cai DH, Song YF. Identification of immune feature genes and intercellular profiles in diabetic cardiomyopathy. <i>World J Diabetes</i> 2024; 15(10): 2093-2110</p>
URL	https://www.wjgnet.com/1948-9358/full/v15/i10/2093.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i10.2093

Full Article (PDF)	WJD-15-2093-with-cover.pdf
Manuscript File	90940_Auto_Edited_011645.docx
Answering Reviewers	90940-answering-reviewers.pdf
Audio Core Tip	90940-audio.mp3
Biostatistics Review Certificate	90940-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	90940-conflict-of-interest-statement.pdf
Copyright License Agreement	90940-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90940-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	90940-non-native-speakers.pdf
Peer-review Report	90940-peer-reviews.pdf
Journal Editor-in-Chief Review Report	90940-journal-editor-in-chief.pdf
Scientific Misconduct Check	90940-scientific-misconduct-check.jpg
Scientific Editor Work List	90940-scientific-editor-work-list.pdf
CrossCheck Report	90940-crosscheck-report.pdf