Publication Name	World Journal of Gastroenterology
Manuscript ID	90995
Country	China

Received	2024-01-14 15:10
Peer-Review Started	2024-01-14 15:10
To Make the First Decision
Return for Revision	2024-03-07 06:33
Revised	2024-03-18 03:11
Second Decision	2024-04-25 02:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-25 06:06
Articles in Press	2024-04-25 06:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-10 09:19
Publish the Manuscript Online	2024-05-20 09:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Minireviews
Article Title	Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene: Hypotheses and conundrums
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Xin Xie, Yue Li, Ai-Ming Yang, Dong Wu and Qiang Wang
Funding Agency and Grant Number	Funding Agency Grant Number National High-Level Hospital Clinical Research Fund 2022-PUMCH-A-020 Undergraduate Teaching Reform and Innovation Project 2022zlgc0108
Corresponding Author	Qiang Wang, MD, Assistant Professor, Department of Gastroenterology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. pekingunion@aliyun.com
Key Words	SLCO2A1; Prostaglandin E2; Chronic enteropathy associated with the SLCO2A1 gene; Small intestine; Macrophage
Core Tip	Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a complex gastroenterological condition characterized by multiple ulcers in the small intestine with chronic bleeding and protein loss. This review explores potential mechanisms underlying the pathogenesis of CEAS, focusing on the role of SLCO2A1-encoded prostaglandin transporter OATP2A1 and its impact on prostaglandin E2 (PGE2) levels. Studies suggest that elevated PGE2 levels contribute to mucosal damage, inflammation, and disruption of the intestinal barrier. The effects of PGE2 on macrophage activation, Maxi-Cl channel functionality, and its interaction with nonsteroidal anti-inflammatory drugs also play crucial roles in the progression of CEAS. Understanding the delicate balance of its protective and pro-inflammatory effects as well as the complex interactions within the gastrointestinal tract can shed light on potential therapeutic targets for CEAS and guide the development of novel, targeted therapies.
Publish Date	2024-05-20 09:15
Citation	<p>Xie ZX, Li Y, Yang AM, Wu D, Wang Q. Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene: Hypotheses and conundrums. <i>World J Gastroenterol</i> 2024; 30(19): 2505-2511</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i19/2505.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i19.2505

Full Article (PDF)	WJG-30-2505-with-cover.pdf
Manuscript File	90995_Auto_Edited-YJP.docx
Answering Reviewers	90995-Answering reviewers.pdf
Audio Core Tip	90995-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	90995-Conflict-of-interest statement.pdf
Copyright License Agreement	90995-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90995-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	90995-Language certificate.pdf
Peer-review Report	90995-Peer-review(s).pdf
Scientific Misconduct Check	90995-Bing-Wang JJ-2.png
Scientific Editor Work List	90995-Scientific editor work list.pdf
CrossCheck Report	90995-CrossCheck report.pdf