Publication Name	World Journal of Clinical Oncology
Manuscript ID	91092
Country	Poland

Received	2023-12-21 13:11
Peer-Review Started	2023-12-21 13:11
To Make the First Decision
Return for Revision	2024-01-30 09:42
Revised	2024-02-03 12:14
Second Decision	2024-03-22 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-22 06:29
Articles in Press	2024-03-22 06:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-10 01:44
Publish the Manuscript Online	2024-04-22 09:51

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Britanin – a beacon of hope against gastrointestinal tumors?
Manuscript Source	Invited Manuscript
All Author List	Agnieszka Kajdanek, Damian Kołat, Lin-Yong Zhao, Mateusz Kciuk, Zbigniew Pasieka and Żaneta Kałuzińska-Kołat
Funding Agency and Grant Number
Corresponding Author	Żaneta Kałuzińska-Kołat, BSc, MSc, Research Assistant, Teaching Assistant, Department of Biomedicine and Experimental Surgery, Medical University of Lodz, Narutowicza 60, Lodz 90-136, Lodzkie, Poland. zaneta.kaluzinska@umed.lodz.pl
Key Words	Britanin; Sesquiterpene lactones; Chemotherapeutics; Gastrointestinal tumors; In vitro; In vivo
Core Tip	Natural compounds have settled in the development of novel drugs. Britanin is a sesquiterpene lactone whose effect on gastrointestinal tumors has not been summarized before. Our paper reviews the current state of knowledge and proposes novel research directions. Britanin was found to counteract liver, colorectal, pancreatic, and gastric tumors via the regulation of proliferation, apoptosis, autophagy, immune response, migration, and angiogenesis. Future research should examine the link between Britanin and acetylcholinesterase, mast cells, osteolysis, and ischemia. The compound holds promise as an anti-cancer agent and may overcome the paucity of treatment options or high mortality rate in gastrointestinal tumors.
Publish Date	2024-04-22 09:51
Citation	Kajdanek A, Kołat D, Zhao LY, Kciuk M, Pasieka Z, Kałuzińska-Kołat Ż. Britanin – a beacon of hope against gastrointestinal tumors? World J Clin Oncol 2024; 15(4): 523-530
URL	https://www.wjgnet.com/2218-4333/full/v15/i4/523.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i4.523

Full Article (PDF)	WJCO-15-523-with-cover.pdf
Manuscript File	91092_Auto_Edited-YJP.docx
Answering Reviewers	91092-Answering reviewers.pdf
Audio Core Tip	91092-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91092-Conflict-of-interest statement.pdf
Copyright License Agreement	91092-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	91092-Language certificate.pdf
Peer-review Report	91092-Peer-review(s).pdf
Scientific Misconduct Check	91092-CrossCheck.png
Scientific Misconduct Check	91092-Bing-Gong ZM-2.png
Scientific Editor Work List	91092-Scientific editor work list.pdf