Publication Name	World Journal of Stem Cells
Manuscript ID	91095
Country	China

Received	2023-12-21 15:07
Peer-Review Started	2023-12-21 15:07
To Make the First Decision
Return for Revision	2024-02-03 02:37
Revised	2024-02-17 04:09
Second Decision	2024-03-15 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-15 07:02
Articles in Press	2024-03-15 07:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-22 01:35
Publish the Manuscript Online	2024-04-25 05:24

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Review
Article Title	Mesenchymal stem cells and their derived exosomes for the treatment of COVID-19
Manuscript Source	Invited Manuscript
All Author List	Xiang-Yi Hou, La-Mu Danzeng, Yi-Lin Wu, Qian-Hui Ma, Zheng Yu, Mei-Ying Li and Li-Sha Li
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Department Project of Jilin Province, China 20230101163JC Outstanding Youth Fund Project of Jilin Provincial Department of Education, China JJKH20241324KJ
Corresponding Author	Li-Sha Li, PhD, Professor, The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, No. 126 Xinmin Street, Changchun 130021, Jilin Province, China. lilisha@jlu.edu.cn
Key Words	COVID-19; Cytokine storm; Immunomodulation; Mesenchymal stem cell; Mesenchymal stem cell-derived exosomes
Core Tip	As the coronavirus disease 2019 (COVID-19) pandemic normalizes, developing efficient treatments is critical to reducing the strain on the healthcare system. We summarize the various current treatments for COVID-19 and the mechanisms of damage caused by severe acute respiratory syndrome coronavirus 2. Through the comparison to existing treatments, we find that stem cell therapy has more research value. Mesenchymal stem cells (MSC) and their derived exosomes (MSC-Exo) have homing, immunomodulatory, and tissue repair abilities. They can reduce lung injury and inhibit pulmonary fibrosis. We summarized the clinical trials in recent years, analyzed the safety and effectiveness of MSC and MSC-Exo treatment from various aspects such as mechanism of action and therapeutic effect, and provided substantial theoretical support for their clinical application.
Publish Date	2024-04-25 05:24
Citation	Hou XY, Danzeng LM, Wu YL, Ma QH, Yu Z, Li MY, Li LS. Mesenchymal stem cells and their derived exosomes for the treatment of COVID-19. World J Stem Cells 2024; 16(4): 353-374
URL	https://www.wjgnet.com/1948-0210/full/v16/i4/353.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i4.353

Full Article (PDF)	WJSC-16-353-with-cover.pdf
Manuscript File	91095_Auto_Edited-YJP.docx
Answering Reviewers	91095-Answering reviewers.pdf
Audio Core Tip	91095-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91095-Conflict-of-interest statement.pdf
Copyright License Agreement	91095-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91095-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	91095-Language certificate.pdf
Peer-review Report	91095-Peer-review(s).pdf
Scientific Misconduct Check	91095-Bing-Wang JJ-2.png
Scientific Editor Work List	91095-Scientific editor work list.pdf
CrossCheck Report	91095-CrossCheck report.pdf