| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Peng Hou, Xiang-Qin Qin, Wei-Wei Hou, Yun-Yi Han, Qi-Jing Bo, Fang Dong, Fu-Chun Zhou, Xian-Bin Li and Chuan-Yue Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81971250 |
| Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support |
ZLRK202335 |
| Early Psychosis Cohort Program of Beijing Anding Hospital |
ADDL-03 |
|
| Corresponding Author |
Chuan-Yue Wang, MD, PhD, Professor, Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, No. 5 Ankang Lane, Dewai Avenue, Xicheng District, Beijing 100088, China. wang_cy@ccmu.edu.cn |
| Key Words |
Catechol-O-methyltransferase Val/Met polymorphism; Cognitive reserve; Crystallized intelligence; Negative symptoms; Schizophrenia |
| Core Tip |
Cognitive reserve (CR) and the catechol-O-methyltransferase (COMT) Val/Met polymorphism are reportedly linked to negative symptoms, which are a core clinical manifestation of schizophrenia. However, the regulatory effect of the COMT genotype on the relationship between CR and negative symptoms is unclear. In this study, COMT Met-carriers exhibited fewer negative symptoms than Val homozygotes. Information and similarities showed interaction effects with the COMT genotype in terms of negative symptoms. This preliminary study shows that the association between negative symptoms and CR may be under the regulation of the COMT genotype in schizophrenia. |
| Publish Date |
2024-05-16 07:58 |
| Citation |
<p>Hou WP, Qin XQ, Hou WW, Han YY, Bo QJ, Dong F, Zhou FC, Li XB, Wang CY. Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia. <i>World J Psychiatry</i> 2024; 14(5): 695-703</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v14/i5/695.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v14.i5.695 |
