Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	91237
Country	Türkiye

Received	2023-12-25 13:27
Peer-Review Started	2023-12-25 13:27
To Make the First Decision
Return for Revision	2024-02-26 09:11
Revised	2024-03-08 21:30
Second Decision	2024-03-22 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-22 06:36
Articles in Press	2024-03-22 06:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-15 02:36
Publish the Manuscript Online	2024-04-19 03:18

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Retrospective Study
Article Title	Prognostic significance of tumor budding, desmoplastic reaction, and lymphocytic infiltration in patients with gastric adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Ayşen Yavuz, Kubra Simsek, Anil Alpsoy, Busra Altunay, Elif Ocak Gedik, Betul Unal, Cumhur Ibrahim Bassorgun, Ali Murat Tatli and Gulsum Ozlem Elpek
Funding Agency and Grant Number
Corresponding Author	Gulsum Ozlem Elpek, MD, Professor, Department of Pathology, Akdeniz University Medical School, Dumlupinar Bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr
Key Words	Gastric cancer; Tumor budding; Desmoplastic stroma; Tumor-infiltrating lymphocytes; Prognosis
Core Tip	This study investigated the relationships between tumor budding, desmoplastic reaction (DR), and tumor-infiltrating lymphocytes (TILs) in patients with gastric adenocarcinomas (GAC) and assessed their influence on prognosis. Our results demonstrated that TB is a promising prognostic factor in GAC. While it could also be valuable in determining survival in patients with unresectable tumors, further studies are needed to draw a conclusion. Although the DR and TILs were not observed as independent parameters, their close association with TB in patients with GAC suggests their value in predicting tumor behavior merits further research to clarify their roles better.
Publish Date	2024-04-19 03:18
Citation	Yavuz A, Simsek K, Alpsoy A, Altunay B, Gedik EO, Unal B, Bassorgun CI, Tatli AM, Elpek GO. Prognostic significance of tumor budding, desmoplastic reaction, and lymphocytic infiltration in patients with gastric adenocarcinoma. World J Gastrointest Pathophysiol 2024; 15(1): 91237
URL	https://www.wjgnet.com/2150-5330/full/v15/i1/91237.htm
DOI	https://dx.doi.org/10.4291/wjgp.v15.i1.91237

Full Article (PDF)	WJGP-15-91237-with-cover.pdf
Manuscript File	91237_Auto_Edited-YJP.docx
Answering Reviewers	91362-Answering reviewers.pdf
Audio Core Tip	91362-Audio core tip.m4a
Biostatistics Review Certificate	91237-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	91237-Conflict-of-interest statement.pdf
Copyright License Agreement	91237-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	91237-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	91237-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	91237-Language certificate.pdf
Peer-review Report	91237-CrossCheck report.pdf
Peer-review Report	91237-Peer-review(s).pdf
Scientific Misconduct Check	91237-Bing-Chen YL-2.png
Scientific Editor Work List	91237-Scientific editor work list.pdf