Publication Name	World Journal of Stem Cells
Manuscript ID	91250
Country	Saudi Arabia

Received	2023-12-25 16:06
Peer-Review Started	2023-12-25 16:06
To Make the First Decision
Return for Revision	2024-01-11 06:31
Revised	2024-01-11 17:34
Second Decision	2024-01-29 02:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-29 06:07
Articles in Press	2024-01-29 06:07
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-02-02 03:38
Typeset the Manuscript	2024-03-04 02:16
Publish the Manuscript Online	2024-03-25 02:43

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Editorial
Article Title	High glucose microenvironment and human mesenchymal stem cell behavior
Manuscript Source	Invited Manuscript
All Author List	Muhammad Abdul Mateen, Nouralsalhin Alaagib and Khawaja Husnain Haider
Funding Agency and Grant Number
Corresponding Author	Khawaja Husnain Haider, BPharm, BSc, PhD, Chairman, Full Professor, Professor, Cellular and Molecular Pharmacology, Sulaiman AlRajhi Medical School, PO Box 777, Al Bukairiyah 51941, Saudi Arabia. kh.haider@sr.edu.sa
Key Words	Adipose tissue; Apoptosis; Bioenergetics; Cell survival; Cell therapy; Hyperglycemia; Mitochondria; Mesenchymal stem cells; Stem cells
Core Tip	High glucose (HG) conditions, seen in vitro as well as in diabetic patients, adversely affect stem cells by disrupting the mammalian target of rapamycin- phosphoinositide 3-kinase-Akt signaling, resulting in reduced cell survival and increased apoptosis. A recent study on adipose tissue-derived mesenchymal stem cells (MSCs) found dysregulation of this signaling pathway and defective mitochondrial membrane potential (MtMP) under HG conditions. This leads to decreased ATP production, heightened oxidative stress, and structural abnormalities, causing diminished cell survival. Altered mitochondrial NAD+/NADH redox state and disrupted mitochondrial homeostasis worsen the hostile microenvironment induced by HG exposure. These findings are a note of caution for using MSCs from hyperglycemic donors in cell-based therapy due to their poor survival and proliferation rates. Future research targeting MtMP restoration may enhance the therapeutic efficacy of MSCs in hyperglycemic patients.
Publish Date	2024-03-25 02:43
Citation	Mateen MA, Alaagib N, Haider KH. High glucose microenvironment and human mesenchymal stem cell behavior. World J Stem Cells 2024; 16(3): 237-244
URL	https://www.wjgnet.com/1948-0210/full/v16/i3/237.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i3.237

Full Article (PDF)	WJSC-16-237-with-cover.pdf
Manuscript File	91250-Review-Filipodia.docx
Answering Reviewers	91250-Answering reviewers.pdf
Audio Core Tip	91250-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91250-Conflict-of-interest statement.pdf
Copyright License Agreement	91250-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	91250-Language certificate.pdf
Peer-review Report	91250-Peer-review(s).pdf
Scientific Misconduct Check	91250-Bing-Wang JJ-2.png
Scientific Editor Work List	91250-Scientific editor work list.pdf
CrossCheck Report	91250-CrossCheck report.pdf