| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Autophagy-dependent ferroptosis may play a critical role in early stages of diabetic retinopathy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Jie Sun, Xue-Dong An, Yue-Hong Zhang, Shan-Shan Tang, Yu-Ting Sun, Xiao-Min Kang, Lin-Lin Jiang, Xue-Fei Zhao, Qing Gao, Hang-Yu Ji and Feng-Mei Lian |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
82305205 |
| the clinical research business fund of the Central High-level Traditional Chinese Medicine Hospital |
HLCMHPP2023084 |
| Chinese Association of Traditional Chinese Medicine (2023-2025) Youth Talent Support Project |
CACM-2023-QNRC2-A05 |
|
| Corresponding Author |
Feng-Mei Lian, PhD, Professor, Department of Endocrinology, Guang’anmen Hospital, No. 5 Beixiange, Xicheng District, Beijing 100053, China. lfm565@sohu.com |
| Key Words |
Diabetic retinopathy; Diabetes mellitus; Retinal neurovascular unit; Autophagy-dependent ferroptosis; Early stage; Mechanisms |
| Core Tip |
This article initially investigates the early pathological alterations of diabetic retinopathy (DR), with a particular emphasis on the retinal neurovascular unit (NVU) as a pivotal focal point in the initial stage of DR. Recent studies have revealed that ferroptosis may exert a significant role in the early phase of DR. Autophagy-dependent ferroptosis -related factors, including BECN1 and FABP4, could potentially serve as biomarkers for the onset and progression of DR, thereby representing promising targets for effective treatment strategies in the future. These findings provide novel insights into understanding the mechanisms underlying early pathological changes in DR and offer supplementary avenues for innovative research on treatment approaches. |
| Publish Date |
2024-10-16 10:39 |
| Citation |
<p>Sun WJ, An XD, Zhang YH, Tang SS, Sun YT, Kang XM, Jiang LL, Zhao XF, Gao Q, Ji HY, Lian FM. Autophagy-dependent ferroptosis may play a critical role in early stages of diabetic retinopathy. <i>World J Diabetes</i> 2024; 15(11): 2189-2202</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i11/2189.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i11.2189 |
