Publication Name	World Journal of Gastroenterology
Manuscript ID	91371
Country	Greece

Received	2023-12-27 15:20
Peer-Review Started	2023-12-28 01:36
To Make the First Decision
Return for Revision	2024-01-16 08:12
Revised	2024-02-20 01:39
Second Decision	2024-03-28 01:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-28 02:38
Articles in Press	2024-03-28 02:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-11 01:18
Publish the Manuscript Online	2024-04-19 08:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Combination treatment of inflammatory bowel disease: Present status and future perspectives
Manuscript Source	Invited Manuscript
All Author List	John K Triantafillidis, Constantinos G Zografos, Manousos M Konstadoulakis and Apostolos E Papalois
Funding Agency and Grant Number
Corresponding Author	John K Triantafillidis, PhD, N/A, N/A, Inflammatory Bowel Disease Unit, "Metropolitan General" Hospital, 264 Mesogeion Avenue, Holargos 15562, Attica, Greece. jktrian@gmail.com
Key Words	Biologics for immune-mediated conditions; Dual-targeted treatment; Combination treatment; Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis
Core Tip	During the last few years, the combination of two biological agents or a combination of a biological agent and another drug belonging to the category of so-called "small molecules" seems to be steadily gaining ground [dual biologic therapy (DBT)]. Even the combination of a biological agent with a drug belonging for example to the category of immunosuppressants is a therapeutic option that has been applied for several years [combination therapy (CT)]. Finally, in daily clinical practice, various combinations of so-called first-line drugs (mesalazine, corticosteroids, antibiotics, probiotics, etc.) are used with satisfactory results in most cases. DBT and CT currently find application in cases of patients resistant to treatment or patients with extraintestinal manifestations that do not respond satisfactorily to classical treatment. The existing data, although encouraging, are not sufficient in terms of the number of patients included so far. The safety of this emerging kind of treatment is another point of interest. Finally, there is a need to carry out more studies regarding this interesting field of research.
Publish Date	2024-04-19 08:45
Citation	Triantafillidis JK, Zografos CG, Konstadoulakis MM, Papalois AE. Combination treatment of inflammatory bowel disease: Present status and future perspectives. World J Gastroenterol 2024; 30 (15)：2068-2080
URL	https://www.wjgnet.com/1007-9327/full/v30/i15/2068.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i15.2068

Full Article (PDF)	WJG-30-2068-with-cover.pdf
Manuscript File	91371_Auto_Edited-YJP.docx
Answering Reviewers	91371-Answering reviewers.pdf
Audio Core Tip	91371-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91371-Conflict-of-interest statement.pdf
Copyright License Agreement	91371-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	91371-Language certificate.pdf
Peer-review Report	91371-Peer-review(s).pdf
Scientific Misconduct Check	91371-Bing-Li L-2.png
Scientific Editor Work List	91371-Scientific editor work list.pdf
CrossCheck Report	91371-CrossCheck.png
CrossCheck Report	91371-CrossCheck report.pdf