Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	91381
Country	Thailand

Received	2023-12-27 17:20
Peer-Review Started	2023-12-27 17:20
To Make the First Decision
Return for Revision	2024-02-05 06:03
Revised	2024-02-17 17:22
Second Decision	2024-03-19 02:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-19 07:30
Articles in Press	2024-03-19 07:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-15 05:43
Publish the Manuscript Online	2024-05-09 13:59

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Editorial
Article Title	Interleukin-1β: Friend or foe for gastrointestinal cancers
Manuscript Source	Invited Manuscript
All Author List	Kullanat Khawkhiaw, Jutatip Panaampon, Thanit Imemkamon and Charupong Saengboonmee
Funding Agency and Grant Number	Funding Agency Grant Number National Research Council of Thailand N41A640108 Mekong-Lancang Cooperation Special Fund The Development and Promotion of Science and Technology Talents Project Ministry of Education, Science, Sports, and Culture of Japan 22K16327 Ministry of Education, Science, Sports, and Culture of Japan 22K08482
Corresponding Author	Charupong Saengboonmee, MD, PhD, Assistant Professor, Doctor, Department of Biochemistry, Faculty of Medicine, Khon Kaen University, 123 Mitraphap Highway, Khon Kaen 40002, Thailand. charusa@kku.ac.th
Key Words	Cancer; Gastrointestinal tract; Inflammation; Interleukin-1β; Tumor microenvironment
Core Tip	Interleukin-1β (IL-1β) is a pro-inflammatory cytokine primarily secreted by leukocytes to activate the immune response at the site of infection or inflammation. As tumor-promoting inflammation is one of the cancer hallmarks, IL-1β then plays central roles in tumor-promoting activities in many cancers, including cancers of the gastrointestinal tract. On the other hand, by activating and recruiting immune cells into the tumor microenvironments, IL-1β also has anti-tumor effects depending on the subtypes of immune cells that respond and infiltrate into the tumor site. Whether it could be a promising target for future therapeutic development is then discussed in this article.
Publish Date	2024-05-09 13:59
Citation	Khawkhiaw K, Panaampon J, Imemkamon T, Saengboonmee C. Interleukin-1β: Friend or foe for gastrointestinal cancers. World J Gastrointest Oncol 2024; 16(5): 1676-1682
URL	https://www.wjgnet.com/1948-5204/full/v16/i5/1676.htm
DOI	10.4251/wjgo.v16.i5.1676

Full Article (PDF)	WJGO-16-1676-with-cover.pdf
Manuscript File	91381_Auto_Edited-YJP.docx
Answering Reviewers	91381-Answering reviewers.pdf
Audio Core Tip	91381-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	91381-Conflict-of-interest statement.pdf
Copyright License Agreement	91381-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91381-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	91381-Language certificate.pdf
Peer-review Report	91381-Peer-review(s).pdf
Scientific Misconduct Check	91381-Bing-Fan JR-2.png
Scientific Editor Work List	91381-Scientific editor work list.pdf
CrossCheck Report	91381-CrossCheck report.pdf
CrossCheck Report	91381-CrossCheck.png