Publication Name	World Journal of Clinical Oncology
Manuscript ID	91481
Country	China

Received	2024-01-02 14:11
Peer-Review Started	2024-01-02 14:11
To Make the First Decision
Return for Revision	2024-01-13 00:55
Revised	2024-01-23 13:55
Second Decision	2024-02-21 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-02-21 06:30
Articles in Press	2024-02-21 06:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-08 07:07
Publish the Manuscript Online	2024-03-22 11:48

ISSN	2218-4333 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	PD-1 antibody in combination with chemotherapy for the treatment of SMARCA4-deficient advanced undifferentiated carcinoma of the duodenum: Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Nan Shi, Xiao-Rui Zhang, Wei-Yu Ma, Jing Lian, Yan-Feng Liu, Yi-Fan Li and Wen-Hui Yang
Funding Agency and Grant Number
Corresponding Author	Wen-Hui Yang, PhD, Associate Chief Physician, Department of Gastroenterology and Hepatology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, No. 3 Zhigong Xin Street, Taiyuan 030013, Shanxi Province, China. yangwenhui-10012@163.com
Key Words	SMARCA4 deficiency; Undifferentiated carcinomas; Chemotherapy; Programmed death 1; Immune checkpoint inhibitors
Core Tip	SMARCA4-deficient malignancies arising from the gastrointestinal tract are rare and have a poor prognosis. We present two patients diagnosed with advanced duodenal undifferentiated carcinoma by immunohistochemical staining for SMARCA4 deficiency and TP53 gene mutations. Patients with high tumor mutational burden responded well to programmed death 1 antibodies in combination with chemotherapy, and those with liver metastases had a worse prognosis.
Publish Date	2024-03-22 11:48
Citation	Shi YN, Zhang XR, Ma WY, Lian J, Liu YF, Li YF, Yang WH. PD-1 antibody in combination with chemotherapy for the treatment of SMARCA4-deficient advanced undifferentiated carcinoma of the duodenum: Two case reports. World J Clin Oncol 2024; 15(3): 456-463
URL	https://www.wjgnet.com/2218-4333/full/v15/i3/456.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i3.456

Full Article (PDF)	WJCO-15-456-with-cover.pdf
CARE Checklist–2016	91481-CARE Checklist (2016).pdf
Manuscript File	91481_Auto_Edited-YJP.docx
Answering Reviewers	91481-Answering reviewers.pdf
Audio Core Tip	91481-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	91481-Conflict-of-interest statement.pdf
Copyright License Agreement	91481-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	91481-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	91481-Language certificate.pdf
Peer-review Report	91481-Peer-review(s).pdf
Scientific Misconduct Check	91481-CrossCheck.png
Scientific Misconduct Check	91481-Bing-Gong ZM-2.png
Scientific Editor Work List	91481-Scientific editor work list.pdf
CrossCheck Report	91481-CrossCheck report.pdf