Publication Name	World Journal of Stem Cells
Manuscript ID	91577
Country	Jordan

Received	2023-12-30 21:22
Peer-Review Started	2023-12-30 21:22
To Make the First Decision
Return for Revision	2024-01-23 06:21
Revised	2024-02-05 21:06
Second Decision	2024-03-11 02:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-18 06:04
Articles in Press	2024-03-18 06:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-17 13:17
Publish the Manuscript Online	2024-04-25 05:24

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Effects of high glucose and severe hypoxia on the biological behavior of mesenchymal stem cells at various passages
Manuscript Source	Invited Manuscript
All Author List	Fatimah Almahasneh, Ejlal Abu-El-Rub, Ramada R Khasawneh and Rawan Almazari
Funding Agency and Grant Number	Funding Agency Grant Number Deanship of Scientific Research, Yarmouk University, Jordan 73/2022
Corresponding Author	Ejlal Abu-El-Rub, PharmD, PhD, Assistant Professor, Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid-Shafiq Irshidat Street, Irbid 21163, Jordan. ejlal.abuelrub@yu.edu.jo
Key Words	Mesenchymal stem cells; High glucose; Hypoxia; Stressful microenvironment; Serial passage; Senescence; Apoptosis
Core Tip	Mesenchymal stem cells (MSCs) are increasingly being used for the treatment of various diseases due to their immunomodulatory and regenerative properties, but serial passages needed for MSCs expansion and stress factors found in the diseased tissues may compromise their therapeutic potential. Investigating the effects of stress factors (high glucose and severe hypoxia) on the biological characteristics of MSCs at different passages will help optimize the clinical uses of MSCs and their expected outcomes.
Publish Date	2024-04-25 05:24
Citation	Almahasneh F, Abu-El-Rub E, Khasawneh RR, Almazari R. Effects of high glucose and severe hypoxia on the biological behavior of mesenchymal stem cells at various passages. World J Stem Cells 2024; 16(4): 434-443
URL	https://www.wjgnet.com/1948-0210/full/v16/i4/434.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i4.434

Full Article (PDF)	WJSC-16-434-with-cover.pdf
Manuscript File	91577_Auto_Edited-YJP.docx
Answering Reviewers	91577-Answering reviewers.pdf
Audio Core Tip	91577-Audio core tip.mp3
Biostatistics Review Certificate	91577-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	91577-Conflict-of-interest statement.pdf
Copyright License Agreement	91577-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91577-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	91577-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	91577-Language certificate.pdf
Peer-review Report	91577-Peer-review(s).pdf
Scientific Misconduct Check	91577-Bing-Wang JJ-2.png
Scientific Editor Work List	91577-Scientific editor work list.pdf