Publication Name	World Journal of Gastroenterology
Manuscript ID	91786
Country	Greece

Received	2024-01-05 09:42
Peer-Review Started	2024-01-05 09:42
To Make the First Decision
Return for Revision	2024-01-15 03:41
Revised	2024-01-24 16:39
Second Decision	2024-03-28 01:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-28 02:21
Articles in Press	2024-03-28 02:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-07 23:01
Publish the Manuscript Online	2024-04-19 08:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Editorial
Article Title	Understanding autoimmune pancreatitis: Clinical features, management challenges, and association with malignancies
Manuscript Source	Invited Manuscript
All Author List	Grigorios Christodoulidis, Marina Nektaria Kouliou and Konstantinos Eleftherios Koumarelas
Funding Agency and Grant Number
Corresponding Author	Grigorios Christodoulidis, MD, PhD, Academic Editor, Department of General Surgery, University Hospital of Larissa, University of Thessaly, Biopolis Campus, Larissa 41110, Greece. gregsurg09@gmail.com
Key Words	Autoimmune pancreatitis; Immunoglobulin G4-related disease; Pancreatic cancer; Surgery
Core Tip	Autoimmune pancreatitis (AIP) is a unique form of pancreatitis, categorized into AIP-1 and AIP-2, with distinct clinical characteristics and associations. AIP-1, linked to elevated immunoglobulin G4 (IgG4) levels, exhibits higher relapse rates and predominantly affects older males, while AIP-2 is less common and associated with inflammatory bowel disease. Recognized as a manifestation of IgG4-related systemic disease, AIP poses an increased risk of malignancies, especially gastric, colorectal, and bladder cancers. Despite ongoing debates about the association with pancreatic cancer, careful diagnostic evaluation, including biopsy and response to steroids, is crucial for informed decision-making regarding surgery. AIP patients may have concurrent PanINs but generally experience better long-term outcomes compared to pancreatic cancer patients. Steroids remain the primary treatment, and emerging biomarkers like interferon alpha and interleukin-33 offer promising avenues for monitoring and managing AIP.
Publish Date	2024-04-19 08:45
Citation	Christodoulidis G, Kouliou MN, Koumarelas KE. Understanding autoimmune pancreatitis: Clinical features, management challenges, and association with malignancies. World J Gastroenterol 2024; 30 (15)：2091-2095
URL	https://www.wjgnet.com/1007-9327/full/v30/i15/2091.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i15.2091

Full Article (PDF)	WJG-30-2091-with-cover.pdf
Manuscript File	91786_Auto_Edited-YJP.docx
Answering Reviewers	91786-Answering reviewers.pdf
Audio Core Tip	91786-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91786-Conflict-of-interest statement.pdf
Copyright License Agreement	91786-Copyright license agreement.pdf
Peer-review Report	91786-Peer-review(s).pdf
Scientific Misconduct Check	91786-Bing-Wang JJ-2.png
Scientific Editor Work List	91786-Scientific editor work list.pdf