Publication Name	World Journal of Gastroenterology
Manuscript ID	91833
Country	China

Received	2024-01-06 14:36
Peer-Review Started	2024-01-06 14:36
To Make the First Decision
Return for Revision	2024-02-02 20:24
Revised	2024-02-15 13:44
Second Decision	2024-03-25 01:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-25 01:38
Articles in Press	2024-03-25 01:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-03 03:56
Publish the Manuscript Online	2024-04-12 16:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Ju Sun, Bo Jiao, Yan Wang, Yue-Hua Zhang, Ge Chen, Zi-Xuan Wang, Hong Zhao, Qing Xie and Xiao-Hua Song
Funding Agency and Grant Number
Corresponding Author	Xiao-Hua Song, PhD, Professor, Department of Gastroenterology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Medical Group), No. 127 Siliu South Road, Qingdao 266042, Shandong Province, China. sxh72@sina.com
Key Words	Nonalcoholic fatty liver disease; Apoptosis; Necroptosis; Cell death; Diagnosis; Treatment
Core Tip	Hepatocyte death has been hypothesized as a major contributor to nonalcoholic fatty liver disease (NAFLD) progression, however, the role of regulated cell death (RCD) programs in NAFLD pathophysiology and their potential as diagnostic/therapeutic strategies has not been comprehensively discussed. The present study reviewed the participation of pyroptosis, ferroptosis, and necroptosis in the establishment of NAFLD and its progression toward steatohepatitis and cancer and discussed the potential RCDs in the diagnosis/treatment of the disease. Particularly, the present findings revealed that necroptosis significantly contributes to NAFLD occurrence and progress that may represent promising functions as diagnostic/therapeutic tools.
Publish Date	2024-04-12 16:45
Citation	Sun HJ, Jiao B, Wang Y, Zhang YH, Chen G, Wang ZX, Zhao H, Xie Q, Song XH. Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions. World J Gastroenterol 2024; 30(14): 1968-1981
URL	https://www.wjgnet.com/1007-9327/full/v30/i14/1968.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i14.1968

Full Article (PDF)	WJG-30-1968-with-cover.pdf
Manuscript File	91833_Auto_Edited-YJP.docx
Answering Reviewers	91833-Answering reviewers.pdf
Audio Core Tip	91833-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91833-Conflict-of-interest statement.pdf
Copyright License Agreement	91833-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	91833-Language certificate.pdf
Peer-review Report	91833-Peer-review(s).pdf
Scientific Misconduct Check	91833-Bing-Wang JJ-2.png
Scientific Editor Work List	91833-Scientific editor work list.pdf