Publication Name	World Journal of Gastroenterology
Manuscript ID	92027
Country	China

Received	2024-01-15 13:05
Peer-Review Started	2024-01-13 02:21
To Make the First Decision
Return for Revision	2024-04-07 20:16
Revised	2024-04-22 17:32
Second Decision	2024-05-09 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-09 03:14
Articles in Press	2024-05-09 03:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-27 15:42
Publish the Manuscript Online	2024-05-27 09:35

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Development and validation of a new prognostic model for patients with acute-on-chronic liver failure in intensive care unit
Manuscript Source	Unsolicited Manuscript
All Author List	Zong-Yi Zhu, Xiu-Hong Huang, Hui-Qing Jiang and Li Liu
Funding Agency and Grant Number
Corresponding Author	Li Liu, MD, Chief Physician, Department of Gastroenterology, The Second Hospital of Hebei Medical University, No. 215 West Road, Shijiazhuang 050000, Hebei Province, China. loraliu@163.com
Key Words	Acute-on-chronic liver failure; Cirrhosis; Risk stratification; Prognosis; Model; Scores
Core Tip	Patients with acute-on-chronic liver failure (ACLF) usually need to be hospitalized in intensive care unit for condition monitoring and organ support therapy where existing prognostic scores for ACLF have a limited predictive accuracy. In this study, we developed a new prognostic model [Medical Information Mart for Intensive Care (MIMIC) ACLF] using data in MIMIC database for patients with ACLF. MIMIC ACLF not only exhibited a satisfactory predictive accuracy and clinical utility in MIMIC cohort, but also performed well in external single and multiple-center validation cohorts. In addition, we performed a risk stratification and developed an online calculator based on MIMIC ACLF to facilitate its application in clinical practice.
Publish Date	2024-05-27 09:35
Citation	<p>Zhu ZY, Huang XH, Jiang HQ, Liu L. Development and validation of a new prognostic model for patients with acute-on-chronic liver failure in intensive care unit. <i>World J Gastroenterol</i> 2024; 30(20): 2657-2676</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i20/2657.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i20.2657

Full Article (PDF)	WJG-30-2657-with-cover.pdf
STROBE Statement	92027-STROBE statement.pdf
Manuscript File	92027_Auto_Edited-YJP.docx
Answering Reviewers	92027-Answering reviewers.pdf
Audio Core Tip	92027-Audio core tip.mp3
Biostatistics Review Certificate	92027-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	92027-Conflict-of-interest statement.pdf
Copyright License Agreement	92027-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	92027-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	92027-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	92027-Language certificate.pdf
Peer-review Report	92027-Peer-review(s).pdf
Scientific Misconduct Check	92027-Bing-Lin C-2.png
Scientific Editor Work List	92027-Scientific editor work list.pdf
CrossCheck Report	92027-CrossCheck.png
CrossCheck Report	92027-CrossCheck report.pdf