Publication Name	World Journal of Stem Cells
Manuscript ID	92182
Country	China

Received	2024-01-18 00:58
Peer-Review Started	2024-01-18 00:58
To Make the First Decision
Return for Revision	2024-03-09 06:28
Revised	2024-03-18 11:24
Second Decision	2024-04-07 00:13
Accepted by Journal Editor-in-Chief	2024-04-08 06:08
Accepted by Executive Editor-in-Chief	2024-04-09 06:06
Articles in Press	2024-04-09 06:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-13 09:18
Publish the Manuscript Online	2024-05-24 08:33

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Hepatocyte growth factor enhances the ability of dental pulp stem cells to ameliorate atherosclerosis in apolipoprotein E-knockout mice
Manuscript Source	Unsolicited Manuscript
All Author List	Han Duan, Ning Tao, Lin Lv, Kai-Xin Yan, Yong-Gang You, Zhuang Mao, Chang-Yao Wang, Xue Li, Jia-Yan Jin, Chu-Tse Wu and Hua Wang
Funding Agency and Grant Number
Corresponding Author	Hua Wang, PhD, Research Scientist, N/A, Beijing Institute of Radiation Medicine, No. 27 Taiping Road, Beijing 100850, China. 18511712135@163.com
Key Words	Atherosclerosis; Apolipoprotein E-knockout mice; Cell therapy; Dental pulp stem cells; Hepatocyte growth factor
Core Tip	In this study, we found that dental pulp stem cell (DPSC) treatment reduced atherosclerotic plaque formation in apolipoprotein E-knockout (ApoE-/-) mice fed a high-fat diet and that Ad-hepatocyte growth factor (HGF) modified DPSC (DPSC-HGF) treatment was more effective than Ad-Null modified DPSC (DPSC-Null) treatment, which depended on the reduced expression of aortic endothelial cell adhesion molecule and inflammatory macrophages. In addition, DPSC-HGF had a greater inhibitory effect on the nuclear factor-κB signaling pathway in RAW264.7 cells and HAOECs cells under inflammatory stimulation than DPSC-Null. Taken together, these data suggest for the first time that DPSC treatment can ameliorate AS in ApoE-/- mice and that DPSC-HGF has more impressive therapeutic potential than DPSC-Null and might be a new therapy for AS patients in the future.
Publish Date	2024-05-24 08:33
Citation	<p>Duan H, Tao N, Lv L, Yan KX, You YG, Mao Z, Wang CY, Li X, Jin JY, Wu CT, Wang H. Hepatocyte growth factor enhances the ability of dental pulp stem cells to ameliorate atherosclerosis in apolipoprotein E-knockout mice. <i>World J Stem Cells</i> 2024; 16(5): 575-590</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i5/575.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i5.575

Full Article (PDF)	WJSC-16-575-with-cover.pdf
Full Article (Word)	WJSC-16-575.docx
The ARRIVE Guidelines	92182-The ARRIVE guidelines.pdf
Manuscript File	92182_Auto_Edited-YJP.docx
Answering Reviewers	92182-Answering reviewers.pdf
Audio Core Tip	92182-Audio core tip.mp3
Biostatistics Review Certificate	92182-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	92182-Conflict-of-interest statement.pdf
Copyright License Agreement	92182-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	92182-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	92182-Language certificate.pdf
Peer-review Report	92182-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	92182-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	92182-Bing-Wang JJ-2.png
Scientific Editor Work List	92182-Scientific editor work list.pdf
CrossCheck Report	92182-CrossCheck report.pdf