| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian-Di Li, Rong-Quan He, Yi-Wu Dang, Zhi-Guang Huang, Dan-Dan Xiong, Lu Zhang, Xiu-Fang Du and Gang Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. NSFC82160762 |
| National Natural Science Foundation of China |
No. NSFC82460783 |
| Natural Science Foundation of Guangxi |
No. 2022GXNSFBA035657 |
| Innovation Project of Guangxi Graduate Education |
No. JGY2023068 |
| Innovation Project of Guangxi Graduate Education |
No. YCSW2023220 |
|
| Corresponding Author |
Gang Chen, PhD, Professor, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. chengang@gxmu.edu.cn |
| Key Words |
Transmembrane protein 106C; Pan-cancers; Liver hepatocellular carcinoma; Molecular biology; Nitidine chloride |
| Core Tip |
Herein, we conducted the first study to investigate the expression implications, immune associations, and transcriptional regulatory mechanisms of transmembrane protein 106C (TMEM106C) across 34 cancer types, including liver hepatocellular carcinoma (LIHC). Our multicenter study represents the largest investigation to date of the expression pattern and biological functions of TMEM106C in LIHC. Of particular note, our study discovered the inhibitory effect of nitidine chloride on TMEM106C overexpression, which has not been reported previously. |
| Publish Date |
2025-01-18 08:12 |
| Citation |
<p>Li JD, He RQ, Dang YW, Huang ZG, Xiong DD, Zhang L, Du XF, Chen G. Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2025; 17(2): 92437</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i2/92437.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i2.92437 |
