| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Salivary metabolites are promising noninvasive biomarkers of drug-induced liver injury
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Si-Miao Yu, Hao-Cheng Zheng, Si-Ci Wang, Wen-Ya Rong, Ping Li, Jing Jing, Ting-Ting He, Jia-Hui Li, Xia Ding and Rui-Lin Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical Education Association Foundation of China |
2020KTY001 |
| National Natural Science Foundation of China |
81673806 |
| National Natural Science Foundation Youth Fund |
82104702 |
|
| Corresponding Author |
Rui-Lin Wang, Department of Hepatology of Traditional Chinese Medicine, The Fifth Medical Center of PLA General Hospital, No. 100 Middle Road, West Fourth Ring Road, Beijing 100039, China. wrl7905@163.com |
| Key Words |
Drug-Induced liver injury; Salivary; Metabolomics; Biomarker; Weighted metabolite Coexpression network analysis; Machine learning; Noninvasive; Diagnostic method; Metabolites |
| Core Tip |
Drug-induced liver injury (DILI) is one of the most common and serious adverse reactions to drugs. Conventional biomarkers are not specific and there is an urgent need for a non-invasive DILI marker. Our study has revealed a significant difference in salivary metabolites between patients with DILI and healthy individuals, and identified five metabolites that can distinguish DILI from healthy control, namely 12-hydroxydodecanoic acid, 3-hydroxydecanoic acid, tetradecanedioic acid, hypoxanthine, and inosine. Our study may provide a potential feasible non-invasive diagnostic method for DILI. |
| Publish Date |
2024-05-11 10:58 |
| Citation |
<p>Yu SM, Zheng HC, Wang SC, Rong WY, Li P, Jing J, He TT, Li JH, Ding X, Wang RL. Salivary metabolites are promising noninvasive biomarkers of drug-induced liver injury. <i>World J Gastroenterol</i> 2024; 30(18): 2454-2466</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i18/2454.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i18.2454 |
