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Publication Name World Journal of Gastroenterology
Manuscript ID 93117
Country China
2024-02-20 07:31
Peer-Review Started
2024-02-20 07:31
To Make the First Decision
Return for Revision
2024-03-12 01:34
2024-04-05 10:13
Second Decision
2024-04-18 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-04-18 03:04
Articles in Press
2024-04-18 03:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2024-05-08 02:53
Publish the Manuscript Online
2024-05-11 10:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Salivary metabolites are promising noninvasive biomarkers of drug-induced liver injury
Manuscript Source Invited Manuscript
All Author List Si-Miao Yu, Hao-Cheng Zheng, Si-Ci Wang, Wen-Ya Rong, Ping Li, Jing Jing, Ting-Ting He, Jia-Hui Li, Xia Ding and Rui-Lin Wang
Funding Agency and Grant Number
Funding Agency Grant Number
Medical Education Association Foundation of China 2020KTY001
National Natural Science Foundation of China 81673806
National Natural Science Foundation Youth Fund 82104702
Corresponding Author Rui-Lin Wang, Department of Hepatology of Traditional Chinese Medicine, The Fifth Medical Center of PLA General Hospital, No. 100 Middle Road, West Fourth Ring Road, Beijing 100039, China. wrl7905@163.com
Key Words Drug-Induced liver injury; Salivary; Metabolomics; Biomarker; Weighted metabolite Coexpression network analysis; Machine learning; Noninvasive; Diagnostic method; Metabolites
Core Tip Drug-induced liver injury (DILI) is one of the most common and serious adverse reactions to drugs. Conventional biomarkers are not specific and there is an urgent need for a non-invasive DILI marker. Our study has revealed a significant difference in salivary metabolites between patients with DILI and healthy individuals, and identified five metabolites that can distinguish DILI from healthy control, namely 12-hydroxydodecanoic acid, 3-hydroxydecanoic acid, tetradecanedioic acid, hypoxanthine, and inosine. Our study may provide a potential feasible non-invasive diagnostic method for DILI.
Publish Date 2024-05-11 10:58
Citation <p>Yu SM, Zheng HC, Wang SC, Rong WY, Li P, Jing J, He TT, Li JH, Ding X, Wang RL. Salivary metabolites are promising noninvasive biomarkers of drug-induced liver injury. <i>World J Gastroenterol</i> 2024; 30(18): 2454-2466</p>
URL https://www.wjgnet.com/1007-9327/full/v30/i18/2454.htm
DOI https://dx.doi.org/10.3748/wjg.v30.i18.2454
Full Article (PDF) WJG-30-2454-with-cover.pdf
STROBE Statement 93117-STROBE statement.pdf
Manuscript File 93117_Auto_Edited-YJP.docx
Answering Reviewers 93117-Answering reviewers.pdf
Audio Core Tip 93117-Audio core tip.m4a
Biostatistics Review Certificate 93117-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 93117-Conflict-of-interest statement.pdf
Copyright License Agreement 93117-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 93117-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 93117-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 93117-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 93117-Language certificate.pdf
Supplementary Material 93117-Supplementary material.pdf
Peer-review Report 93117-Peer-review(s).pdf
Scientific Misconduct Check 93117-Bing-Qu XL-2.jpg
Scientific Editor Work List 93117-Scientific editor work list.pdf